Synthesis of Indoles Using Cyclization of Imidoyl Radicals

Abstract

Imidoyl radicals, generated from imidoyl phenylselanide precursors, have been used for the synthesis of 2,3-disubstituted indoles. A facile high yielding synthesis of imidoyl phenylselanides has been developed. The potential for neophyl rearrangement of 5-exo radical intermediates to 6-endo radical intermediates is discussed.

Key words

radicals - radical reactions - indoles - cyclizations - rearrangements

References

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We thank Professor Mario D. Bachi, Weizmann Institute, Rehevot, Israel for providing us with unpublished results.