Synthesis of 1,3,4-Thiadiazoles from Aldehyde Hydrazones

Kentaro Okuma; Kazuko Nagakura; Yasutaka Nakajima; Kento Kubo; Kosei Shioji

doi:10.1055/s-2004-829156

SHORTPAPER

Synthesis of 1,3,4-Thiadiazoles from Aldehyde Hydrazones

Kentaro Okuma*, Kazuko Nagakura, Yasutaka Nakajima, Kento Kubo, Kosei Shioji
Department of Chemistry, Faculty of Science, Fukuoka University, Jonan-ku, Fukuoka 814-0180, Japan
Fax: +81(92)8656030; e-Mail: kokuma@fukuoka-u.ac.jp;

Abstract

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Abstract

Reaction of p-tolualdehyde hydrazone with disulfur dichloride in the presence of DBU gave 2,5-di (p-tolyl)-1,3,4-thiadiazole (1a) in 54% yield. Phenyldiazomethane also reacted with disulfur dichloride to afford 2,5-diphenyl-1,3,4-thiadiazole (1b) in 80% yield.

Key words

hydrazone - disulfur dichloride - 1,3,4-thiadiazole - phenyldiazomethane

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