Download PDF
Dtsch Med Wochenschr 2004; 129(16): 884-888
DOI: 10.1055/s-2004-823035
Übersichten
Kardiologie / Geriatrie
© Georg Thieme Verlag Stuttgart · New York

Alter und koronare Herzkrankheit

Age and coronary heart diseaseM. Lins1 , R. Simon1
  • 1Klinik für Kardiologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel
Further Information

Publication History

eingereicht: 8.12.2003

akzeptiert: 18.3.2004

Publication Date:
08 April 2004 (online)

Also available at
    Permissions and Reprints

Vordergründig scheinen die beiden Begriffe koronare Herzerkrankung (KHK) und Alter zwangsläufig miteinander verbunden zu sein. Zahlreiche epidemiologische Studien zeigen einen Zusammenhang zwischen der Entwicklung und dem Fortschreiten der KHK und dem Lebensalter der Patienten.

Literatur

  • 1 Adams M R, Nakagoni A, Keech A. et al . Carotid intima-media thickness is only weakly correlated with the extent and severity of coronary artery disease.  Circulation. 1995;  92 2127-34
    Google Scholar
  • 2 Anonymous. Comparison of coronary bypass surgery with angioplasty in patients with multivessel disease.  N Engl J Med. 1996;  335 217-225
    Google Scholar
  • 3 Batchelor W B, Anstrom K J, Muhlbaier L H. et al . Contemporary outcome trends in the elderly undergoing percutaneous coronary interventions: results in 7,472 octogenarians.  J Am Coll Cardiol. 2000;  36 723-730
    Google Scholar
  • 4 Baumhäkel M, Böhm M. Kardiovaskuläre Pharmakotherapie im Alter.  Internist. 2003;  44 943-50
    Google Scholar
  • 5 Burkhardt H, Gladisch R. Pharmakotherapie des älteren Menschen aus klinischer Sicht.  Internist. 2003;  44 959-967
    Google Scholar
  • 6 CABRI Trial Participants . First-year results of CABRI (Coronary Angioplasty versus Bypass Revascularisation Investigation).  Lancet. 1995;  346 1179-1184
    Google Scholar
  • 7 Carriè D, Elbaz M, Puel J. et al . Five-year outcome after coronary angioplasty versus bypass surgery in multivessel coronary artery disease. Results from the french monocentric study.  Circulation. 1997;  96 II1-II6 (suppl II)
    Google Scholar
  • 8 Clarkson T B. Nohuman primate models of atherosclerosis.  Lab Animal Sci. 1998;  48 569-572
    Google Scholar
  • 9 Cohen H A, Williams D O, Holmes D R. et al . NHLBI Dynamic Registry. Impact of age on procedural and 1-year outcome in percutaneous transluminal coronary angioplasty: a report from the NHLBI Dynamic Registry.  Am Heart J. 2003;  146 51 351-9
    Google Scholar
  • 10 Davis K B, Chaitman B, Thomas R. et al . Comparison of 15-year survival for men and women after initial medical or surgical treatment for coronary artery disease: a cass registry study.  JACC. 1995;  25 1000-1009
    Google Scholar
  • 11 Detre K M, Myler R K, Kelsey S F. et al . Baseline charakcteristics of patients in the national heart, lung and blood institute percutaneous transluminal coronary angioplasty registry.  Am J Cardiol. 1984;  54 7C-11C
    Google Scholar
  • 12 Eagle G. et al . ACC/AHA Guidelines for coronary artery bypass graft surgery: executive summary and recommendations.  JACC. 1999;  34 1262-1347
    Google Scholar
  • 13 Effert S, Merx W, Meyer J. Revaskularisation des Myokards. Transluminale Koronardilatation - Intrakoronare selektive Thrombolyse.  Deutsches Ärzteblatt. 1981;  17 807-816
    Google Scholar
  • 14 Heidrich J, Wellmann J, Hense H W. et al . Klassische Risikofaktoren für Herzinfarkt und Gesamtsterblichkeit in der Bevölkerung.  Z Kardiol. 2003;  92 445-454
    Google Scholar
  • 15 Homma S, Hirose N, Ishida H. et al . Carotid plaque and intima-media thickness assessed by b-mode ultrasonography in subjects ranging from young adults to centenarians.  Stroke. 2001;  32 830-835
    Google Scholar
  • 16 Jensen L O, Thayssen P, Kassis E, Rasmussen K, Saunamaki K, Thuesen L. Percutaneous coronary intervention in Denmark from 1989 to 1998. Results from the Danish PTCA registry.  Ugeskr Laeger. 2003;  165 2809-2812
    Google Scholar
  • 17 King S B, Lembo N J, Weintraub W S. et al . For the emory angioplasty versus surgery trial (EAST). A randomized trial comparing coronary angioplasty with coronary bypass surgery.  N Engl Med. 1994;  331 1044-1050
    Google Scholar
  • 18 Ko W, Gold J P, Lazzaro R, Zelano J A. et al . Survival analysis of octogenarian patients with coronary artery disease managed by elective coronary artery bypass surgery versus conventional medical treatment.  Circulation. 1992;  86 191-7 (suppl II)
    Google Scholar
  • 19 Kobayashi Y, Mehran R, Mintz G S. et al . Comparison of in-hospital and one-year outcomes after multiple coronar arterial stenting in patients > or = 80 years old versus those > 80 years.  Am J Cardiol. 2003;  92 443-446
    Google Scholar
  • 20 Kotamaki M, Strandberg T E, Nieminen M S. Clinical findings, outcome and treatment in patients > or = 75 years acute myocardial infarction.  Eur J Epidemiol. 2003;  18 781-786
    Google Scholar
  • 21 Kowalchuk G J, Siu S C, Lewis S M. Coronary artery disease in the octogenarian: angiographic spectrum and suitability for Revascularisationcularization.  Am J Cardiol. 1990;  66 1319-1323
    Google Scholar
  • 22 Lakatta E G, Levy D. Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises. Part I: Aging Arteries: A „Set Up” for Vascular Disease.  Circulation. 2003;  107 139-46
    Google Scholar
  • 23 Lakatta E G, Levy D. Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises. Part II: The Aging Heart in Health: Links to Heart Disease.  Circulation. 2003;  107 346-354
    Google Scholar
  • 24 Lakatta E G. Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises. Part III: Cellular and Molecular Clues to Heart and Arterial Aging.  Circulation. 2003;  107 490-497
    Google Scholar
  • 25 Lakatta E G. Cardiovascular regulatory mechanism in advanced age.  Physiol Rev. 1993;  73 413-465
    Google Scholar
  • 26 Lefkowitz R, Willerson J. Prospects for cardiovascular research.  JAMA. 2001;  285 581-587
    Google Scholar
  • 27 Magnus P, Beaglehole R. The real contribution of the major risk factors on the coronary epidemics. Time to end the „only-50 %” myth.  Arch Intern Med. 2001;  161 2657-2660
    Google Scholar
  • 28 Mullany C J, Darling G E, Pluth J R. et al . Early and late results after isolated coronary artery bypass surgery in 159 patients aged 80 years and older.  Circulation. 1990;  82 229-236 (suppl IV)
    Google Scholar
  • 29 Nagai Y, Metter J, Earley C J. et al . Increased carotid artery intimal-medial thickness in asymptomatic older subjects with exercise-induced myocardial ischemia.  Circulation. 1998;  98 1504-1509
    Google Scholar
  • 30 Parisi A F, Folland E D, Hartigan P. on behalf of the veterans affairs AGME Investigators . A Comparison of angioplasty with medical therapy in the treatment of single-vessel coronary artery disease.  N Engl J Med. 1992;  326 10-16
    Google Scholar
  • 31 Peterson E D, Cowper P A, Jollis J G. et al . Outcomes of coronary artery bypass graft surgery in 24 461 patients aged 80 years or older.  Circulation. 1995;  92 85-91 (suppl II)
    Google Scholar
  • 32 RITA trial participants . Coronary angioplasty versus coronary artery bypass surgery: the radomised intervention treatment of angina (RITA) trial.  Lancet. 1993;  341 573-580
    Google Scholar
  • 33 Rodriguez A, Boullon F, Perez-Balino N. et al. On behalf of the ERACI Group . Argentine randomized trial of percutaneous transluminal coronary angioplasty versus coronary artery bypass surgery in multivessel disease (ERACI): In-hospital results an 1-year follow-up.  JACC. 1993;  22 1060-1067
    Google Scholar
  • 34 Serruys P W, Unger F, Sousa J E. et al . Comparsion of coronary-artery bypass surgery and stenting for the treatment of multivessel disease: For the arterial revascularization therapies study group.  N Engl J Med. 2001;  344 1117-1124
    Google Scholar
  • 35 Spagnoli L G, Orlandi A, Mauriello A. et al . Aging and atherosclerosis in the rabbit: distribution, prevalence, and morphology of atherosclerotic lesions.  Atherosclerosis. 1991;  89 11-24
    Google Scholar
  • 36 The SoS Investigators . Coronary artery bypass surgery versus percutaneous coronary intervention with stent implantation in patients with multivessel coronary artery disease (the Stent of Surgery trial): a randomised controlled trial.  Lancet. 2002;  360 965-70
    Google Scholar
  • 37 Tedesco J V, Williams B A, Wright R S, Reeder G S, Dvorak D, Kopecky S L, Miller H. Coronary Care Unit Group . Baseline comorbidities and treatment strategy in elderly patients are associated with outcome of cardiogenic shock in a community-based population.  Am Heart J. 2003;  146 472-478
    Google Scholar
  • 38 Virmani R, Avolio A P, Mergner V J. et al . Effect of aging on aortic morphology in populations with high an low prevalence of hypertension an atherosclerosis: comparison between occidental and Chinese communities.  Am J Pathol. 1991;  139 1119-1129
    Google Scholar
  • 39 Williams D B, Traad E A, Carrillo R G. et al . Determinants of operative mortality in octogenarians undergoing coronary bypass.  Ann Thorac Surg. 1995;  60 1038-1043
    Google Scholar

Priv.-Doz. Dr. Markus Lins

Klinik für Kardiologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel

Schittenhelmstraße 12

24105 Kiel

Phone: +49/431/5971440

Fax: +49/431/5971470

Email: lins@cardio.uni-kiel.de

      >