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Synthesis 2004(6): 942-948
DOI: 10.1055/s-2004-822321
DOI: 10.1055/s-2004-822321
PAPER
© Georg Thieme Verlag Stuttgart · New YorkA Simple One-Pot Synthesis of 2,6-Disubstituted 4-(Polyfluoroalkyl)pyridines and -pyrimidines by Reaction of 2-Polyfluoroalkylchromones with Aromatic Methyl Ketimines and Amidines
Further Information
Received
4 February 2004
Publication Date:
25 March 2004 (online)
Publication History
Publication Date:
25 March 2004 (online)

Abstract
The reaction of 2-polyfluoroalkylchromones with ketimines, derived from aromatic methyl ketones and isopropylamine, gives 2,6-diaryl-4-polyfluoroalkylpyridines in moderate to low yields. Benzamidine and guanidine also react with 2-polyfluoroalkylchromones to afford the corresponding 2,6-disubstituted 4-polyfluoroalkylpyrimidines.
Key words
2-polyfluoroalkylchromones - ketimines - amidines - 4-polyfluoroalkylpyridines and -pyrimidines
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