Synlett 2004(3): 540-542  
DOI: 10.1055/s-2004-815407
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© Georg Thieme Verlag Stuttgart · New York

Free Radical-Mediated Tandem Reaction of Dehydroamino Acid Derivative with π-Allyl Palladium Complex: Synthesis of α,α-Disubstituted Amino Acids

Hideto Miyabe, Ryuta Asada, Kazumasa Yoshida, Yoshiji Takemoto*
Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan
Fax: +81(75)7534569; e-Mail: takemoto@pharm.kyoto-u.ac.jp;
Further Information

Publication History

Received 1 December 2003
Publication Date:
12 January 2004 (online)

Abstract

The diethylzinc-promoted reaction of dehydroamino acid derivative with electrophilic π-allyl palladium complex ­proceeded smoothly to afford α,α-disubstituted amino acids via a tandem radical and anionic carbon-carbon bond forming processes.