A Facile Synthesis of Derivatives of (1,3,4-Thiadiazol-2-yl)glycine and Its Phosphonyl Analogue

Abstract

The adducts formed by 4-functionally-substituted 2-aryl-5-hydrazino-1,3-oxazoles and aryl isothiocyanates recyclize on heating to produce the hitherto unknown derivatives of (1,3,4-thiadiazol-2-yl)glycine and its phosphonyl analogue.

Key words

α-aminocarboxylic acids - α-aminoalkylphosphonic acids - (1,3,4-thiadiazol-2-yl)glycine - 1,3-oxazoles - 3,3-dichloroacrylates - 2,2,2-trichloroethylphosphonates - aryl isothiocyanates

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Full crystallographic details have been deposited at Cambridge Crystallographic Data Centre (CCDC). Any request to the CCDC for this material, should quote the full literature citation and reference number CCDC 215589.