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Semin Respir Crit Care Med 2003; 24(4): 445-454
DOI: 10.1055/s-2003-42379
DOI: 10.1055/s-2003-42379
Drug-Induced Lung Disease: A Pragmatic Classification Incorporating HRCT Appearances
Further Information
Publication History
Publication Date:
18 October 2003 (online)
ABSTRACT
Drug-induced lung disease frequently poses a diagnostic challenge. Knowledge of common radiological patterns of lung involvement and corresponding histopathologic diagnoses can facilitate management of individual patients. We outline a framework for understanding radiological and histologic patterns of drug-induced lung disease. Diffuse forms of drug-induced lung disease include processes that mimic acute respiratory distress syndrome (ARDS) and diffuse alveolar hemorrhage. These patterns of drug-induced lung disease are especially common in patients receiving cytotoxic chemotherapeutic agents. Chronic forms of drug-induced lung disease include many of the interstitial pneumonias seen more commonly in patients with idiopathic disease. Bronchiolitis obliterans organizing pneumonia and eosinophilic pneumonia are nonspecific patterns of drug-induced lung disease that are radiologically and histologically indistinguishable from their idiopathic counterparts. In some patients organizing pneumonia and eosinophilic pneumonia mimic the radiological appearance of neoplastic disease.
KEYWORDS
Diffuse alveolar damage - nonspecific interstitial pneumonia - usual interstitial pneumonia - bronchiolitis obliterans organizing pneumonia - eosinophilic pneumonia
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