C-Glycosylated Phenylalanine Synthesis by Palladium-Catalyzed Cross-Coupling Reactions

Valérie Boucard; Karen Larrieu; Nadège Lubin-Germain; Jacques Uziel; Jacques Augé

doi:10.1055/s-2003-41416

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C-Glycosylated Phenylalanine Synthesis by Palladium-Catalyzed Cross-Coupling Reactions

Valérie Boucard, Karen Larrieu, Nadège Lubin-Germain*, Jacques Uziel, Jacques Augé*
UMR 8123 CNRS-UCP-ESCOM, 5 Mail Gay-Lussac, Neuville sur Oise, 95031 Cergy-Pontoise Cedex, France
Fax: +33(1)34257067; e-Mail: jacques.auge@chim.u-cergy.fr;

Abstract

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Abstract

A new and convergent synthesis of a C-glycosylated phenylalanine derivative using palladium-catalyzed Stille and Neghishi cross-coupling reactions is described. The coupling product constitutes a precursor of a natural glycosylated tyrosine mime.

Key words

tin - zinc - carbohydrates - amino acids - cross-coupling - palladium

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References

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