Synlett 2003(10): 1463-1464
DOI: 10.1055/s-2003-40858
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Brønsted Acid-Mediated Synthesis of α-Amino Phosphonates under Solvent-Free Conditions

Takahiko Akiyama*, Machiko Sanada, Kohei Fuchibe
Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1, Mejiro, Toshima-ku, Tokyo 171-8588, Japan
Fax: +81(3)59921029; e-Mail: takahiko.akiyama@gakushuin.ac.jp;
Further Information

Publication History

Received 6 May 2003
Publication Date:
24 July 2003 (online)

Abstract

Three-component reactions of aldehydes, amine, and diethyl phosphite by means of CF3COOH under the solvent-free conditions afforded α-amino phosphonates in excellent yields.

21

For the synthesis of α-amino phosphonate under solvent-free conditions, see; refs. [15-17]

22

Acetophenone did not react under the same reaction conditions.