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Synlett 2003(9): 1295-1298
DOI: 10.1055/s-2003-40357
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Rhodium-Catalyzed [5+2] Cycloaddition Reactions in Water

Paul A. Wender*, Jennifer A. Love, Travis J. Williams
Department of Chemistry, Stanford University, Stanford, CA 94305, USA
Fax: +1(650)7250259; e-Mail: wenderp@leland.stanford.edu;
Further Information

Publication History

Received 17 December 2003
Publication Date:
30 June 2003 (online)

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Abstract

A new water-soluble rhodium catalyst is reported along with its ability to effect [5+2] cycloaddition reactions in water. This water-soluble catalyst is recyclable, is readily separated from the organic product, and allows one to avoid or minimize the use of organic solvents, the major waste stream of most organic reactions.

Key words

water-soluble catalyst - biphasic reactions - cycloaddition - medium-sized rings - rhodium

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Commercially available from Strem Chemicals: $121.00 for 1 g, catalog # 15-0155.