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Synthesis 2003(6): 0845-0848
DOI: 10.1055/s-2003-38684
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of N-Tosylguanidines by Ring Cleavage of 1,2-Dihydro-2-tosyliminopyrimidines

Jamal Lasria, M. Eugenia González-Rosendeb, José Sepúlveda-Arques*a
a Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Valencia, Avda. Vicent Andres Estelles s/n, 46100 Burjassot, Valencia, Spain
Fax: +34(96)3864939; e-Mail: jose.sepulveda@uv.es ;
b Departamento de Química, Bioquímica y Biología Molecular, Universidad Cardenal Herrera-CEU, 46113 Moncada, Valencia, Spain
Further Information

Publication History

Received 6 February 2003
Publication Date:
16 April 2003 (online)

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Abstract

The present communication discloses a new synthetic method for the preparation of N-tosylguanidines in high yields by ring cleavage of 1,2-dihydro-2-tosyliminopyrimidines with methyl­amine.

Key words

imines - ring opening - nucleophilic addition - sulfonamides - cleavage

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Fernandez-Ferri, P.; Ubeda, A.; Guillén, I.; Lasri, J.; González-Rosende, M. E.; Akssira, M.; Sepúlveda-Arques, J. Eur. J. Med. Chem. 2003, in press.