Regiospecific Cyclization of 4-Alkoxyvinyl Trifluoro[chloro]methyl Ketones with 6-Trifluoro[chloro]methyl-2-hydrazine Pyrimidines. A Convenient Method to Obtain Trifluoro[chloro]methylated 2-(5-Hydroxy-5-trifluoro[chloro]methyl-4,5-dihydro-1H-Pyrazol-l-yl]-pyrimidines

Nilo Zanatta; Darlene C. Flores; Claudia C. Madruga; Débora Faoro; Alex F. C. Flores; Helio G. Bonacorso; Marcos A. P. Martins

doi:10.1055/s-2003-38680

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Synthesis 2003(6): 0894-0898
DOI: 10.1055/s-2003-38680

PAPER

Regiospecific Cyclization of 4-Alkoxyvinyl Trifluoro[chloro]methyl Ketones with 6-Trifluoro[chloro]methyl-2-hydrazine Pyrimidines. A Convenient Method to Obtain Trifluoro[chloro]methylated 2-(5-Hydroxy-5-trifluoro[chloro]methyl-4,5-dihydro-1H-Pyrazol-l-yl]-pyrimidines

Nilo Zanatta*, Darlene C. Flores, Claudia C. Madruga, Débora Faoro, Alex F. C. Flores, Helio G. Bonacorso, Marcos A. P. Martins
Núcleo de Química de Heterociclos (NUQUIMHE), Departamento de Química, Universidade Federal de Santa Maria, 97.105-900, Santa Maria, RS, Brazil
Fax: +55(55)2208031; e-Mail: zanatta@base.ufsm.br;

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Publication History

Received 27 September 2002
Publication Date:
16 April 2003 (online)

Abstract
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Abstract

The regiospecific synthesis of a novel series of 4-trifluoro[chloro]-2-(5-hydroxy-5-trifluoro[chloro]methyl-4,5-dihydro-1H-pyrazol-1-yl]-pyrimidines from the reactions of 4-alkoxy-1,1,1-trifluoro[chloro]-alk-3-en-2-ones with 6-trifluoro[chloro]methyl-2-hydrazine pyrimidines is presented.

Key words

pyrazolylpyrimidines - pyrazoles - pyrimidines - halogenated heterocycles

References

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