Practical and Scaleable Syntheses of 3-Hydroxythiophenol

Abstract

3-Hydroxythiophenol is a versatile intermediate for the synthesis of medicinal and heterocyclic compounds. Two novel and practical syntheses of 3-hydroxythiophenol are achieved using readily available and inexpensive starting materials. An overall cost comparison of these syntheses is also given.

Key words

3-hydroxythiophenol - Grignard reactions - diazo compounds - sulfur - practical synthesis

References

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1

Author for correspondence. Current address: Department of Chemistry, Bayer Research Center, Pharmaceutical Division, 400 Morgan Lane, West Haven, CT 06516. E-mail: [e-mail]; telephone [phone]; fax [phone]

10

No attempt was made to assess the stability and energy of decomposition of the di-diazonium salt intermediate.