Abstract
A convenient two-step synthesis of the title compounds based
on the isocyanide chemistry is reported. The Ugi four-component
condensation between 4-chloro-2-nitrobenzoic acid (1 ),
aldehydes 2 , cyclohexyl isocyanide (3 ) and α-amino esters as the amino
components afforded the expected nitro compounds 5 which were
reductively cyclized to the desired 1,4-benzodiazepine-2,5-diones 7 via the intermediate amino derivatives 6 .
Key words
heterocycles - cyclizations - diastereoselectivity - condensation - benzodiazepine
- isocyanides
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