Abstract
A convenient selective protection of the α-amino carboxyl
group of amino acids bearing reactive side chain groups such as arginine,
asparagine, glutamine, cysteine, histidine, serine and lysine, using
4-alkoxy-1,1,1-trifluoro[chloro]alk-3-en-2-ones
is reported. The reactions were performed without esterification
of the carboxyl group and N -deprotection
was carried out using a six molar solution of hydrochloric acid.
Key words
ketones - fluorine - halogens - amino
acids - protecting groups
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