A Multicomponent Coupling Strategy for the Synthesis of the Triene Component of the Oxazolomycin Antibiotics

Paul G.  Bulger; Mark G.  Moloney; Paul C.  Trippier

doi:10.1055/s-2002-34905

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Synlett 2002(11): 1871-1873
DOI: 10.1055/s-2002-34905

LETTER

A Multicomponent Coupling Strategy for the Synthesis of the Triene Component of the Oxazolomycin Antibiotics

Paul G. Bulger, Mark G. Moloney*, Paul C. Trippier
The Department of Chemistry, Dyson Perrins Laboratory, The University of Oxford, South Parks Road, Oxford, OX1 3QY, UK
e-Mail: mark.moloney@chem.ox.ac.uk;

Further Information

Publication History

Received 29 August 2002
Publication Date:
21 October 2002 (online)

Abstract
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Abstract

Concise and versatile routes suitable for the synthesis of three geometric isomers of an analogue of the left hand triene sub-unit of oxazolomycin are reported, using a Stille coupling strategy.

Key Words

Stille reaction - natural products - diastereoselectivity - organometallic reagents

References

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Part of this work was presented at the RSC Meeting ‘Recent Advances in the Medicinal Chemistry of Anti-Infective Agents: New Targets and Opportunities’, 23-26 July 2000, Churchill College, Cambridge, UK.