Novel Synthetic Method for 2,3-Dihydro-3-halo-3-methylindole from
N-Acetyl-2-isopropenylaniline by Intramolecular Haloamination

Abstract

We describe a novel, practical method for synthesis of 2,3-dihydro-3-haloindole from an o-aminostyrene derivative via haloamination, in which the protective group on the nitrogen and α-alkyl substituents on styrene are critical.

Key words

2,3-dihydro-3-haloindole - haloamination - o-amino­styrene - NBS - NCS

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