A Novel Synthesis of 2-Trichloromethylchromones and 7-Trichloromethylnorkhellin

Abstract

The reaction of 2-hydroxyacetophenones with trichloroacetyl chloride in the presence of pyridine at -30 °C followed by treatment of the reaction mixture with potassium tert-butylate affords 2-hydroxy-2-trichloromethylchroman-4-ones. Dehydration then provides the 2-trichloromethyl-chromones.

Key words

condensation - 2-hydroxyacetophenones - 2-hydroxy-2-trichloromethylchroman-4-ones - 2-trichloromethylchromones

References

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Sosnovskikh, V. Ya.; Usachev, B. I.; Kodess, M. I. Izv. Akad. Nauk, Ser. Khim. 2002, in press.