Synthesis 2001(6): 0897-0903
DOI: 10.1055/s-2001-13400
PAPER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of N,N-Disubstituted 3-Amino-1,2,4-triazoles

Alan R. Katritzky*a, Boris V. Rogovoya,d, Vladimir Y. Vvedenskya, Katherine Kovalenkoa,b, Peter J. Steelc, Victor I. Markovd, Behrouz Foroode
a Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA
Fax: +1(352)3929199; e-Mail: katritzky@chem.ufl.edu;
b A. E. Arbuzov Institute of Organic and Physical Chemistry, Arbuzov str. 8, Kazan 420088, Russia
c Department of Chemistry, University of Canterbury, Christchurch 1, New Zealand
d Ukrainian State Chemical Technology University (USChTU), Gagarina 8, Dniepropetrovsk, 49005, Ukraine
e Exploratory Chemistry, Trega Biosciences, Inc., 9880 Campus Point Drive, San Diego, CA 92121, USA
Further Information

Publication History

Received 15 September 2000
Publication Date:
24 September 2004 (online)

Abstract

A general method for the synthesis of N,N-disubstituted 3-amino-1,2,4-triazoles 5 from di(benzotriazolyl)methanimines 1 and 1 , hydrazine and substituted hydrazines is developed. The desired compounds were prepared regioselectively under mild conditions by simple procedures in yields of up to 95%.

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