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Semin Respir Crit Care Med 2000; 21(1): 0045-0052
DOI: 10.1055/s-2000-9929
DOI: 10.1055/s-2000-9929
Antibiotic Resistance in Nosocomial Pulmonary Pathogens
Further Information
Publication History
Publication Date:
31 December 2000 (online)
ABSTRACT
Nosocomial pneumonia is the second most common hospital-acquired infection and are associated with antibiotic-resistant microrganisms. In nosocomial pneumonia, both the diagnosis of the disease and the identification of the pathogen agent are controversial. The lack of standard diagnostic criteria can lead to the inappropriate use of broad-spectrum antibiotic therapy and the emergence of multiresistant bacteria. Moreover, empirical antibiotic treatment must be prescribed after bacteriological sample but before culture results because the majority of nosocomial pneumonias require an urgent antibiotic therapy. Most nosocomial pneumonias are of an endogenous origin, particularly in mechanically ventilated patients, and this is associated with a higher rate of multiresistant methicillin-resistant Staphylococcus aureus, Acinetobacter baumanii, Klebsiella pneumoniae with extended spectrum b-lactamases, and Pseudomonadaceae. Multiple factors influence the frequency of pathogens associated with antibiotic resistance, such as duration of hospital stay, time of onset, prior antibiotic therapy, and local microbial ecology.
KEYWORD
Nosocomial pneumonia - pathogen in nosocomial pneumonia - antibiotic resistance
REFERENCES
- 1 Chastre J, Viau F, Brun P. Prospective evaluation of the protected brush specimen for the diagnosis of pulmonary infection in ventilated patients. Am Rev Respir Dis . 1984; 130 924-929
- 2 Fagon J Y, Chastre J, Hance A J. Evaluation of clinical judgment in the identification and treatment of nosocomial pneumonia in ventilated patients. Chest . 1993; 103 547-553
- 3 Kirtland S H, Corley D E, Winterbauer R H. The diagnosis of ventilator-associated pneumonia. A comparison of histologic, microbiologic, and clinical criteria. Chest . 1997; 112 445-457
- 4 Chastre J, Fagon J Y, Bornet-Lesco M. Evaluation of the diagnostic techniques for the diagnosis of nosocomial pneumonia. Am J Respir Crit Care Med . 1995; 152 231-240
- 5 Timsit J F, Misset B, Goldstein F W, Vaury P, Carlet J. Reappraisal of distal diagnostic testings in the diagnostic of ICU acquired pneumonia. Chest . 1995; 108 1632-1639
- 6 Trouillet J L, Chastre J, Vuagnat A. Ventilator-associated pneumonia caused by potentially drug-resistant bacteria. Am J Respir Crit Care Med . 1998; 157 531-539
- 7 American Thoracic Society. Medical Section of the American Lung Association. Hospital-acquired pneumonia in adults: Diagnosis, assessment of the severity, initial antimicrobial therapy, and preventive strategies. Am J Respir Crit Care Med . 1995; 153 1711-1725
- 8 Rodriguez de Castro F, Solé J, Elcuaz R. Quantitative culture of protected brush specimen and bronchoalveolar lavage in ventilated patients without suspected pneumonia. Am J Respir Crit Care Med . 1994; 149 320-323
- 9 Torres A, El-Ebiadry M, Padro L. Validation of different techniques for the diagnosis of ventilator associated pneumonia. Comparison with the immediate postmortem pulmonary biopsy. Am J Respir Crit Care Med . 1994; 149 324-331
- 10 Papazian L, Thomas P, Garbe L. Bronchoscopic or blind bronchial sampling techniques for the diagnosis of ventilator associated pneumonia. Am J Respir Crit Care Med . 1995; 152 1982-1991
- 11 Marquette C H, Copain M C, Wallet F. Diagnostic tests for pneumonia in ventilated patients: Prospective evaluation of diagnostic accuracy using histology as a diagnostic gold standard. Am Rev Respir Dis . 1995; 151 1878-1880
- 12 Torres A, De La Bellaca P J, Xaubet A. Diagnostic value of quantitative cultures of bronchoalveolar lavage and telescoping plugged catheter in mechanically ventilated patients with bacterial pneumonia. Am Rev Respir Dis . 1989; 140 306-310
- 13 Pham L H, Brun-Buisson C, Kegrand P. Diagnosis of nosocomial pneumonia in mechanically ventilated patients: Comparison of a plugged telescoping catheter with the protected brush specimen. Am Rev Respir Dis . 1991; 143 1055-1061
- 14 Johanson W G, Pierce A K, Sanford J. Nosocomial respiratory infections with Gram negative bacilli: The significance of colonization of the respiratory tract. Ann Intern Med . 1972; 77 701-706
- 15 Maunder R J, Harlan M J, Pepe E P. Measurement on plasma fibronectin in patients who develop the adult respiratory stress syndrome. J Lab Clin Med . 1984; 104 583-590
- 16 Garrouste-Orgeas M, Chevret S, Arlet G. Oropharyngeal or gastric colonization and nosocomial pneumonia in adult intensive care unit patients. Am J Resp Care . 1997; 156 1647-1655
- 17 Bonten M JM, Gaillard C A, Van Deer Gest S. The role of intragastric acidity and stress ulcur prophylaxixs on colonization and infection in mechanically ventilated patients: A stratified randomized, double blind study of sulcralfate versus antiacids. Am J Respir Crit Care Med . 1995; 152 1825-1834
- 18 Bonten M JM, Bergmans D C, Ambergen A W. Risk factors for pneumonia, and colonization of respiratory tract and stomach in mechanically ventilated ICU patients. Am J Respir Crit Care Med . 1996; 154 1339-1346
- 19 De Latorre J F, Pont T, Ferrer A. Pattern of tracheal colonization during mechanical ventilation Am J Respir Crit Care Med . 1995; 152 1028-1033
- 20 George D L, Falk P S, Wunderink R G. Epidemiology of ventilator-acquired pneumonia based on protected sampling. Am J Respir Crit Care Med . 1998; 158 1839-1847
- 21 Fourrier F, Duvivier B, Boutigny H. Colonization of dental plaque: A source of nosocomial infections in intensive care unit patients. Crit Care Med . 1998; 26 301-308
- 22 Baxby D, van Saene K F H, Stoutenbeek C P. Selective decontamination of the digestive tract: 13 years on what it is and what it is not. Intensive Care Med . 1996; 22 699-706
- 23 Selective Decontamination of the Digestive Tract Trialist Collaborative Group. Meta-analysis and randomized controlled trials of selective decontamination of the digestive tract. BMJ . 1993; 307 525-532
- 24 Bonten M JM, Gaillard C A, Johanson W G. Colonization in patients receiving and not receiving topical antimicrobial prophylaxis. Am J Respir Care Med . 1994; 150 1332-1340
- 25 Prod'hom G, Leuenberger P, Koerfer J. Nosocomial pneumonia in the mechanically ventilated patients receiving antiacid, ranitidine, or sucralfate as prophylaxis for stress ulcer. A randomized controlled trial. Ann Intern Med . 1994; 120 653-662
- 26 Pingleton S K, Fagon J Y, Leeper K V. Patient selection for the clinical investigation of ventilator associated pneumonia: Criteria for evaluating diagnostic techniques. Chest . 1992; 102(suppl 5) 553S-556S
- 27 Fagon J Y, Chastre J, Domart Y. Nosocomial pneumonia in patients receiving continuous mechanical ventilation. Prospective analysis of 52 episodes with use of a protected specimen brush and quantitative culture techniques. Am Rev Respir Dis . 1989; 139 877-884
- 28 Horan T, Culver D, Jarvis W. Pathogen causing nosocomial infections. Antimicrob Newsletter . 1988; 5 65-67
- 29 Rello J, Ausina V, Ricart M. Impact of previous antimicrobial therapy on the etiolgy and outcome of ventilator associated pneumonia. Chest . 1993; 104 1230-1235
- 30 Jarvis W R, Martone W J. Predominant pathogens in hospital infections. J Antimicrob Chemother . 1992; 29 19-24
- 31 Spencer R C. Predominant pathogens found in the European Prevalence of Infection in Intensive Care Unit. Eur J Clin Microbiol Infect Dis . 1996; 15 281-285
- 32 Bryan C S, Reynolds K L. Bacteremic nosocomial pneumonia. Am Rev Respir Dis . 1984; 129 293
- 33 Yu V L, Kroboth F J, Shonnard J. Legionnaires' disease: New clinical perspective from a prospective pneumonia study. Am J Med . 1982; 73 357-361
- 34 Marrie T J, Haldane D, MacDonald S. Control of endemic nosocomial legionnaires' disease by using sterile potable water for high risk patients. Epidemiol Infec . 1991; 107 591-605
- 35 Nosocomial transmission of multidrug-resistant tuberculosis among HIV-infected persons. Florida and New York, 1988-1991. MMWR Morb Mortal Wkly Rep . 1991; 40 585-591
- 36 Edlin B R, Tokars J I, Grieco M H. An outbreak of multidrug-resistant tuberculosis among hospitalized patients with the aquired immunodeficiency syndrome. N Eng J Med . 1992; 326 1514-1521
- 37 Agerton T, Valway S, Gore B. Transmission of a highly drug-resistant strain (strain W1) of Mycobacterium tuberculosis <~>Community outbreak and nosocomial transmission via a contaminated bronchoscope. JAMA . 1997; 278 1073-1077
- 38 Guidelines for Preventing the Transmission of Mycobacterium tuberculosis in Health-Care Facilities. MMWR Morb Mortal Wkly Rep . 1994; 43(RR13) 1-132
- 39 Maloney S, Pearson M L, Gordon M T. Efficacy of control measures in preventing nosocomial transmission of multidrug-resistant tuberculosis to patients and health care workers. Ann Intern Med . 1995; 122 90-95
- 40 Rello J, Torres A, Ricart M. Staphylococcus aureus: Comparison of methicillin-resistant and methicillin-sensitive episodes. Am J Respir Crit Care Med . 1994; 150 1545-1549
- 41 Timsit J F, Misset B, Renaud B, Goldstein F W, Carlet J. Effect of previous antimicrobials on the accuracy of the main procedures used to diagnose nosocomial pneumonia in ventilated patients. Chest . 1995; 108 1036-1040
- 42 Taylor G D, Buchanam-Chell M, Kirtland T. Bacteremic nosocomial pneumonia. A 7-year experience in one institution. Chest . 1995; 108 786-788
- 43 Tablan O C, Anderson L J, Arden N H. Guidelines for prevention of nosocomial pneumonia. Infect Control Hosp Epidemiol . 1994; 15 587-627
- 44 Craven D E, Steger K S. Nosocomial pneumonia in mechanically ventilated adult patients: Epidemiology and prevention. Semin Respir Infect . 1996; 11 32-53
- 45 Pena C, Pulol M, Ardanuy C. Epidemiology and successful control of a large outbreak due to Klebsiella pneumoniae producing extended-spectrum β-lactamases. Antimicrob Agents Chemother . 1998; 42 53-58
- 46 Meier P A, Carter C D, Wallace S E. A prolonged outbreak of methicillin-resistant Staphylococcus aureus in the burn unit of a tertiary medical center. Infect Control Hosp Epidemiol . 1996; 17 798-8021