Effect of high intensity interval training versus moderate intensity continuous training on appetite control and body composition in adults with Cystic Fibrosis – a randomized controlled study

Objectives: The study aimed to compare the effect of high intensity interval training (HIIT) and moderate intensity continuous training (MICT) on appetite control and body composition in adults with Cystic Fibrosis (CF).

Methods: In a randomized controlled study, 55 people with CF (31f/24m; age: 38±10 y; BMI: 23.9±3.1 kg/m²) with a ppFEV1 of 67.4±19.8% participated in a 3-week training program during an inpatient rehabilitation. They were randomized to two training interventions on a cycle ergometer (30 min with 3 sessions/week) matched for ppFEV1: HIIT (n=26; 10x1 min at 90% peak oxygen uptake, VO_2peak; 2 min rest after each interval) and MICT (n=29; 60% of VO_2peak). Outcome parameters measured at baseline (T0) and the end (T1) of the intervention were: post training ad libitum energy intake (as% of resting energy expenditure, in order to normalize for energy requirement) with a test meal (64% CHO, 13% protein, 23% fat), satiety quotient (assessed by visual analogue scales and normalized for energy intake) and body composition (fat mass, FM; fat-free mass, FFM using bioelectrical impedance analysis).

Results: At baseline, no between group difference in meal energy intake post training were observed (HIIT:+30.7±8.8% REE; MICT:+34.2±9.2% REE; p>0.05) whereas at T1, energy intake tended to be lower in HIIT compared to MICT (+32.5±8.7% REE;+37.9±9.1% REE; p=0.061). Within the MICT group, meal energy intake (% REE) was higher at T1 compared to T0 (p<0.05). The satiety quotient did not differ between the groups at T0 and T1 (p>0.05). In both groups the training intervention led to similar increases in body weight (HIIT:+0.6±1.1 kg; MICT:+0.7±1.1 kg; p<0.05) and FFM (HIIT:+0.8±1.0 kg; MICT:+0.7±1.4 kg; p<0.05). There were no differences in the change of FM between groups (HIIT: -0.3±1.1 kg; MICT:+0.02±1.6 kg; p>0.05). Intervention effects (∆T1-T0) did not differ between groups for all outcome parameters (all p>0.05).

Conclusion: MICT may lead to a higher spontaneous energy compensation after training, whereas both MICT and HIIT 3-week training programs equally increased FFM. These results indicate that people with CF and overweight might benefit more from a HIIT intervention whereas MICT may be more advisable for malnourished people with CF.

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Artikel online veröffentlicht:
22. Mai 2024