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Synthesis
DOI: 10.1055/s-0043-1775493
DOI: 10.1055/s-0043-1775493
paper
One-Pot Sequential Synthesis of Pyrido[2,3-d]pyrimidine-Fused Isoxazoles: Regio-and Chemoselectivity in Green Solvent
Abstract
A new method has been reported for synthesizing derivatives of isoxazolo[4′,5′:5,6]pyrido[2,3-d]pyrimidine through the reaction of arylglyoxal, 1,3-dimethylbarbituric acid, and 5-aminoisoxazole in water as a green solvent. It involves a one-pot sequential multicomponent reaction, which was carried out in two different approaches (with and without purification of 5-aminoisoxazole). The method forms five chemical bonds and offers advantages such as easy product purification, availability of raw materials, high reaction efficiency, and environmental friendliness. This synthetic strategy has the potential to advance developments in heterocyclic chemistry.
Key words
arylglyoxal - 1,3-dimethylbarbituric acid - regioselective - chemoselective - hydroxylamine hydrochloride - four-component reaction - environmental sustainabilitySupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0043-1775493.
- Supporting Information
- CIF File
Publication History
Received: 23 December 2024
Accepted after revision: 29 April 2025
Article published online:
22 May 2025
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