The Retrosynthesis Mindset: A Problem-Solving Tool

Yvonne S. L. Choo; Jacek L. Kolanowski; Jovana V. Milić; Fun Man Fung

doi:10.1055/s-0043-1775406

Synlett, Inhaltsverzeichnis

Synlett 2025; 36(06): 714-718
DOI: 10.1055/s-0043-1775406

letter

Thieme Chemistry Journals Awardees 2024

The Retrosynthesis Mindset: A Problem-Solving Tool

Authors

Yvonne S. L. Choo

^aSchool of Energy and Chemical Engineering, Xiamen University Malaysia, Jalan Sunsuria, Bandar Sunsuria, 43900 Sepang, Selangor Darul Ehsan, Malaysia
Jacek L. Kolanowski

^bInstitute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland

^cVictor Chang Cardiac Research Institute, Darlinghurst, Sydney, NSW, Australia
Jovana V. Milić ∗

^dAdolphe Merkle Institute, University of Fribourg, Ch. des Verdiers 4, 1700 Fribourg, Switzerland
Fun Man Fung ∗

^eDepartment of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore

^fCentre for Teaching, Learning and Technology, National University of Singapore, 15 Kent Ridge Road, Singapore 119225, Singapore

Abstract

Alle Artikel dieser Rubrik

Dedicated to those shaping our retrosynthesis mindset

Abstract

Retrosynthesis refers to the process of deconstructing a target molecule step by step until simpler and commercially available synthetic precursors are identified to develop a valid synthetic pathway. As a powerful problem-solving tool, it has gradually been expanded to other fields of chemistry. The application of a ‘retrosynthesis mindset’ can be relevant beyond chemistry, such as in education, research management, and science advice. In this Letter, we discuss the concept of the retrosynthesis mindset and its implications within and beyond chemistry in the hope of highlighting a broader potential and encouraging the adoption of such a mindset to enhance problem solving and strategic planning across disciplines.

1 Introduction

2 Retrosynthesis Education

3 Retrosynthesis Within and Beyond the Lab

4 Conclusion

Key words

retrosynthesis mindset - problem-solving tool - retrosynthesis - education - research management - science advice

Volltext

Referenzen

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