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Synthesis 2024; 56(16): 2549-2557
DOI: 10.1055/s-0043-1775368
DOI: 10.1055/s-0043-1775368
paper
Synthesis of Methoxy Analogues of Coenzyme Q10 Metabolites from Parsley Seed Extracts via Baeyer–Villiger Rearrangement of Carbonyl-Substituted Polyalkoxybenzenes
Authors
Russian Science Foundation Grant 24-23-00024.
Abstract
Based on the parsley seed main component, apiol, efficient approach to polymethoxyquinone C3- and C4-acids was developed. The key step of this approach is Baeyer–Villiger rearrangement of carbonyl-substituted polyalkoxybenzenes derived from parsley seed extracts. These acids are the MeO-analogues of natural antioxidants – metabolites of ubiquinone and idebenone. Due to antioxidant properties, they are the potential therapeutic candidates for the treatment of mitochondrial dysfunction.
Key words
parsley - apiol - Baeyer–Villiger rearrangement - polymethoxyquinone acids - coenzyme Q10 - antioxidantsSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0043-1775368.
- Supporting Information (PDF)
Publikationsverlauf
Eingereicht: 20. Februar 2024
Angenommen nach Revision: 16. Mai 2024
Artikel online veröffentlicht:
18. Juni 2024
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