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Synfacts 2024; 20(06): 0595
DOI: 10.1055/s-0043-1773281
DOI: 10.1055/s-0043-1773281
Metals in Synthesis
Making Allylamines by 1,4-Carboamination of 1,3-Dienes under Dual Cobalt and Acridine Catalysis
Autor*innen
Zhuang K,
Haug GC,
Wang Y,
Yin S,
Sun H,
Huang S,
Trevino R,
Shen K,
Sun Y,
Huang C,
Qin B,
Liu Y,
Cheng M,
Larionov OV,
*,
Jin S.
*
University of Texas at San Antonio, USA and Shenyang Pharmaceutical University, P.
R. of China
Cobalt-Catalyzed Carbon–Heteroatom Transfer Enables Regioselective Tricomponent 1,4-Carboamination.
J. Am. Chem. Soc. 2024;
146: 8508-8519
DOI: 10.1021/jacs.3c14828
Cobalt-Catalyzed Carbon–Heteroatom Transfer Enables Regioselective Tricomponent 1,4-Carboamination.
J. Am. Chem. Soc. 2024;
146: 8508-8519
DOI: 10.1021/jacs.3c14828
Significance
Merging cobalt and acridine photoredox catalysis enables the decarboxylative coupling of carboxylic acids with 1,3-dienes and aniline derivatives to access aromatic allylic amines.
Comment
This protocol features a broad substrate scope, as also demonstrated by the modification of complex molecules. The reaction can be performed under batch or continuous-flow conditions.
Publikationsverlauf
Artikel online veröffentlicht:
14. Mai 2024
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