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Synfacts 2024; 20(03): 0332
DOI: 10.1055/s-0043-1773014
DOI: 10.1055/s-0043-1773014
Peptide Chemistry
Palladium-Catalyzed Cross-Coupling for the Synthesis of Pyridyl Amino Acids
Authors
Tabanella S,
Valancogne I,
Jackson RF. W.
*
The University of Sheffield, UK
Preparation of Enantiomerically Pure Pyridyl Amino Acids from Serine.
Org. Biomol. Chem. 2003;
1: 4254-4261
DOI: 10.1039/B308750F
Preparation of Enantiomerically Pure Pyridyl Amino Acids from Serine.
Org. Biomol. Chem. 2003;
1: 4254-4261
DOI: 10.1039/B308750F
Significance
Pyridyl amino acids are the crucial building blocks for the synthesis of many bioactive molecules and play a significant role in chemical biology. In 2003, the authors developed a palladium-catalyzed cross-coupling of serine-derived organozinc reagents with halo-substituted pyridines for the synthesis of pyridyl amino acids.
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Comment
A series of pyridyl amino acids was synthesized by palladium-catalyzed cross-coupling of serine-derived organozinc reagents with halo-substituted pyridine.
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Publication History
Article published online:
14 February 2024
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