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Synfacts 2023; 19(12): 1207
DOI: 10.1055/s-0043-17635898
DOI: 10.1055/s-0043-17635898
Metals in Synthesis
Dealkenylative C(sp3)–N Cross-Coupling of Alkenes and Amines by Merging Ozonolysis and Copper Catalysis
Autoren
He Z,
Moreno JA,
Swain M,
Wu J,
Kwon O.
*
University of California, Los Angeles, USA
Aminodealkenylation: Ozonolysis and Copper Catalysis Convert C(sp3)–C(sp2) Bonds to C(sp3)–N Bonds.
Science 2023;
381: 877-886
DOI: 10.1126/science.adi4758
Aminodealkenylation: Ozonolysis and Copper Catalysis Convert C(sp3)–C(sp2) Bonds to C(sp3)–N Bonds.
Science 2023;
381: 877-886
DOI: 10.1126/science.adi4758
Significance
Kwon and co-workers report a novel aminodealkenylation approach to form C(sp3)–N bonds by coupling alkenes and a diverse set of amines. The synthetic utility of this protocol is demonstrated by the preparation of complex bioactive molecules.
Comment
α-Methylstyrene functions as an effective methylation agent within this protocol. Mechanistic investigation such as kinetic studies support the shown mechanism, involving an unusual copper ion pair cooperative process.
Publikationsverlauf
Artikel online veröffentlicht:
15. November 2023
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