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DOI: 10.1055/s-0042-1751393
Simplified Synthesis of an Air-Stable Copper-Complexed Josiphos Ligand via Ugi’s Amine: Complete Preparation and Analysis from Ferrocene
Authors
The project described was supported by the National Institute of General Medical Sciences (R35 GM118055).
This paper is dedicated to Professor David A. Evans (1941–2022), a true teacher and scholar.
Abstract
Ligands containing ferrocene backbones often feature both planar chirality and asymmetric centers, making them attractive options for asymmetric catalysis. Ugi’s amine is a ubiquitous ferrocene-based chiral building block that can be functionalized to form a variety of tunable Josiphos ligands; however, few sources lay out the route from start to finish. Starting from ferrocene, we compile a synthetic route to an air- and moisture-stable copper(I)-Josiphos complex via enantiopure Ugi’s amine, providing a potential one-stop shop for the synthesis of a wide range of Josiphos ligands.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0042-1751393.
- Supporting Information (PDF)
Publikationsverlauf
Eingereicht: 27. Oktober 2022
Angenommen nach Revision: 21. November 2022
Artikel online veröffentlicht:
15. Dezember 2022
© 2022. Thieme. All rights reserved
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