The Connection between HbS Heterozygosity and Unilateral Vision Loss in a Child with Congenital Glaucoma

Background

Hemoglobin-S (HbS) trait, or HbS heterozygosity, is present in 300 million people worldwide [1]. Among the risk factors for HbS sickling crisis have been reported to be dehydration, cold, fever, physical exertion [2], [3], or other factors [4]. To our knowledge this is the first report linking HbS heterozygosity state with visual loss. In our patientʼs case, we identified mechanical stress on the ocular vascular system, produced by an increased intraocular pressure from congenital glaucoma, to be an important pathologic factor in the genesis of occlusive retinal disease and vision loss.

• References

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