Wie gefährlich ist das Zika-Virus?

Zusammenfassung

Das Zika-Virus (ZIKV) kann Mikrozephalien und andere schwere Geburtsschäden verursachen. Das Risiko für Schwangere lässt sich aufgrund der begrenzten epidemiologischen Daten nicht quantifizieren. Durch die bevorstehende Olympiade in Rio ist eine Ausbreitung in Länder mit wenig entwickelten Gesundheitssystemen möglich, die darauf nicht ausreichend vorbereitet sind. Darüber hinaus wird ZIKV sexuell übertragen. Die Pathogenese sexueller Infektionen und die Dauer der Ansteckungsfähigkeit sind unbekannt. Um das von den Olympischen Spielen in Rio ausgehende Risiko zu minimieren, müssen Entwicklungs- und Schwellenländer bei der Prävention unterstützt und das Risiko sexueller Übertragungen genauer untersucht werden.

Abstract

The Zika virus (ZIKV) may cause microcephaly and other serious birth defects. Due to a lack of epidemiological data, the teratogenic risk is unknown. The upcoming Olympic Games in Rio may cause it to spread to unprepared countries with underdeveloped healthcare systems. ZIKV is also sexually transmitted. The pathogenesis of sexual transmission and the duration of contagiousness are currently unknown. To minimize the risks caused by the Olympic Games in Rio, developing and emerging nations must be supported in disease prevention by the WHO and industrialized nations. In addition, the pathogenesis and risks of sexual ZIKV transmission require thorough investigation.

Schlüsselwörter

Zika-Virus - Flavivirus - Epidemie - Olympiade

Keywords

Zika virus - flavivurus - epidemic - Olympics

• Literatur

• 1 Rasmussen SA, Jamieson DJ, Honein MA et al. Zika Virus and Birth Defects – Reviewing the Evidence for Causality. N Engl J Med 2016; 374: 1981-1987
• 2 Johansson MA, Mier YT-RL, Reefhuis J et al. Zika and the Risk of Microcephaly. N Engl J Med 2016;
• 3 Cauchemez S, Besnard M, Bompard P et al. Association between Zika virus and microcephaly in French Polynesia, 2013–15: a retrospective study. Lancet 2016; 387: 2125-2132
• 4 Brasil P, Pereira Jr JP, Raja Gabaglia C et al. Zika Virus Infection in Pregnant Women in Rio de Janeiro – Preliminary Report. N Engl J Med 2016;
• 5 Driggers RW, Ho CY, Korhonen EM et al. Zika Virus Infection with Prolonged Maternal Viremia and Fetal Brain Abnormalities. N Engl J Med 2016; 374: 2142-2151
• 6 Meaney-Delman D, Hills SL, Williams C et al. Zika Virus Infection Among U.S. Pregnant Travelers – August 2015-February 2016. MMWR Morb Mortal Wkly Rep 2016; 65: 211-214
• 7 Mlakar J, Korva M, Tul N et al. Zika Virus Associated with Microcephaly. N Engl J Med 2016; 374: 951-958
• 8 Calvet G, Aguiar RS, Melo AS et al. Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study. Lancet Infect Dis 2016; 16: 653-660
• 9 Martines RB, Bhatnagar J, Keating MK et al. Notes from the Field: Evidence of Zika Virus Infection in Brain and Placental Tissues from Two Congenitally Infected Newborns and Two Fetal Losses – Brazil, 2015. MMWR Morb Mortal Wkly Rep 2016; 65: 159-160
• 10 Cordeiro MT, Pena LJ, Brito CA et al. Positive IgM for Zika virus in the cerebrospinal fluid of 30 neonates with microcephaly in Brazil. Lancet 2016; 387: 1811-1812
• 11 Tang H, Hammack C, Ogden SC et al. Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth. Cell Stem Cell 2016; 18: 587-590
• 12 Garcez PP, Loiola EC, Madeiro da Costa R et al. Zika virus impairs growth in human neurospheres and brain organoids. Science 2016; 352: 816-818
• 13 Cugola FR, Fernandes IR, Russo FB et al. The Brazilian Zika virus strain causes birth defects in experimental models. Nature 2016; 543: 267-271
• 14 Li C, Xu D, Ye Q et al. Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice. Cell Stem Cell 2016; 19: 1-7
• 15 Miner JJ, Cao B, Govero J et al. Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise. Cell 2016; 165: 1081-1091
• 16 Rossi SL, Tesh RB, Azar SR et al. Characterization of a Novel Murine Model to Study Zika Virus. Am J Trop Med Hyg 2016; 96: 1362-1369
• 17 Victora CG, Schuler-Faccini L, Matijasevich A et al. Microcephaly in Brazil: how to interpret reported numbers?. Lancet 387: 621-624
• 18 Banatvala JE, Brown DW. Rubella. Lancet 2004; 363: 1127-1137
• 19 Petersen LR, Jamieson DJ, Powers AM et al. Zika Virus. N Engl J Med 2016; 374: 1552-1563
• 20 Faria NR, Azevedo RdSdS, Kraemer MUG et al. Zika virus in the Americas: Early epidemiological and genetic findings. Science 2016; 352: 345-349
• 21 Wang L, Valderramos SG, Wu A et al. From Mosquitos to Humans: Genetic Evolution of Zika Virus. Cell Host Microbe 2016; 19: 561-565
• 22 World Health Organization. Zika virus and the Olympic and Paralympic Games Rio. 2016 http://www.who.int/mediacentre/news/statements/2016/zika-olympics/en/# (letzter Zugriff: 13. 6. 2016)
• 23 InfoDengue. Situação da Dengue 2015–2016. (04. 06. 2016) Im Internet: https://info.dengue.mat.br/ (letzter Zugriff: 13. 6. 2016)
• 24 Codeco C, Cruz O, Riback TI et al. InfoDengue: a nowcasting system for the surveillance of dengue fever transmission. bioRxiv 2016;
• 25 Bogoch II, Brady OJ, Kraemer MUG et al. Anticipating the international spread of Zika virus from Brazil. Lancet 387: 335-336
• 26 D‘Ortenzio E, Matheron S, Yazdanpanah Y et al. Evidence of Sexual Transmission of Zika Virus. N Engl J Med 2016; 374: 2195-2198
• 27 Hills SL, Russell K, Hennessey M et al. Transmission of Zika Virus Through Sexual Contact with Travelers to Areas of Ongoing Transmission – Continental United States, 2016. MMWR Morb Mortal Wkly Rep 2016; 65: 215-216
• 28 World Health Organization. Prevention of sexual transmission of Zika virus, Interim guidance update (07. 06. 2016). http://www.who.int/csr/resources/publications/zika/sexual-transmission-prevention/en/ (letzter Zugriff: 13. 6. 2016)
• 29 Atkinson B, Hearn P, Afrough B et al. Detection of Zika Virus in Semen. Emerg Infect Dis 2016; 22: 940
• 30 Mansuy JM, Dutertre M, Mengelle C et al. Zika virus: high infectious viral load in semen, a new sexually transmitted pathogen?. Lancet Infect Dis 2016; 16: 405
• 31 Musso D, Roche C, Nhan TX et al. Detection of Zika virus in saliva. J Clin Virol 2015; 68: 53-55
• 32 Robert Koch Institut. Erste sexuelle Übertragung von Zikavirus in Deutschland. Epidemiologisches Bulletin 2016; 20: 179
• 33 Centers for Disease Control. Areas with Zika. http://www.cdc.gov/zika/geo (letzter Zugriff: 13. 6. 2016)
• 34 Ministerio da Saude. Dengue, Chikungunya e Zika – Situacao epidemiologica. http://combateaedes.saude.gov.br/situacao-epidemiologica (letzter Zugriff: 13. 6. 2016)