Parental Height and Weight Influence Offspring Adiposity at 2 Years; Findings from the ROLO Kids Birth Cohort Study

Abstract

Objective The perinatal period and in utero environment are important for fetal growth, development, and fetal programming. This study aimed to determine the effect of parental anthropometry and the maternal metabolic milieu on offspring adiposity at 2 years of age.

Study Design This longitudinal birth cohort includes analysis of maternal (n = 337) and paternal (n = 219) anthropometry and maternal and fetal metabolic markers (n = 337), including glucose, homeostatic model of assessment (HOMA), C-peptide, and leptin from participants of the ROLO (the Randomized Control Trial of Low) pregnancy study, and their partners, to determine an association with offspring anthropometry at two years of age.

Results Linear regression, when adjusted for confounders, indicated maternal and paternal anthropometry and was associated with offspring weight and length at 2 years of age. Maternal height was negatively associated with general adiposity in the total cohort of children (p = 0.002) and in female children (p = 0.006) and central adiposity in the total child cohort (p < 0.001). Paternal height was also negatively associated with general adiposity in all children (p = 0.002) and central adiposity in total (p = 0.023) and female children (p = 0.008). Maternal glucose, insulin resistance, and fetal C-peptide positively correlated with anthropometry in total, male, and female children.

Conclusion Parental anthropometry in the perinatal period has a long-lasting effect on offspring anthropometry beyond the neonatal period. Maternal and fetal metabolic factors influence adiposity, and this extends beyond the perinatal period. Parental adiposity may play a significant role in early childhood adiposity and may be a target for interventions to decrease the risk of early childhood obesity.

Key Points

• Parental height and weight were associated with offspring anthropometry and measures of offspring adiposity at 2 years of age.

• Maternal glucose, insulin resistance, and fetal C-peptide correlated with offspring anthropometry.

• Parental anthropometry has long-term effect on offspring adiposity and is seen at 2 years of age.

Keywords

maternal anthropometry - paternal anthropometry - adiposity - follow-up study

Publikationsverlauf

Eingereicht: 14. April 2021

Angenommen: 24. Oktober 2021

Artikel online veröffentlicht:
29. Dezember 2021

• References

• 1 Wu G, Bazer FW, Cudd TA, Meininger CJ, Spencer TE. Maternal nutrition and fetal development. J Nutr 2004; 134 (09) 2169-2172
• 2 Yu Z, Sun JQ, Haas JD, Gu Y, Li Z, Lin X. Macrosomia is associated with high weight-for-height in children aged 1-3 years in Shanghai, China. Int J Obes 2008; 32 (01) 55-60
• 3 Blair NJ, Thompson JM, Black PN. et al. Risk factors for obesity in 7-year-old European children: the Auckland Birthweight Collaborative Study. Arch Dis Child 2007; 92 (10) 866-871
• 4 Serdula MK, Ivery D, Coates RJ, Freedman DS, Williamson DF, Byers T. Do obese children become obese adults? A review of the literature. Prev Med 1993; 22 (02) 167-177
• 5 Rogers I. EURO-BLCS Study Group. The influence of birthweight and intrauterine environment on adiposity and fat distribution in later life. Int J Obes Relat Metab Disord 2003; 27 (07) 755-777
• 6 Sayer AA, Syddall HE, Dennison EM. et al. Birth weight, weight at 1 y of age, and body composition in older men: findings from the Hertfordshire Cohort Study. Am J Clin Nutr 2004; 80 (01) 199-203
• 7 Stunkard AJ, Harris JR, Pedersen NL, McClearn GE. The body-mass index of twins who have been reared apart. N Engl J Med 1990; 322 (21) 1483-1487
• 8 Silventoinen K, Rokholm B, Kaprio J, Sørensen TI. The genetic and environmental influences on childhood obesity: a systematic review of twin and adoption studies. Int J Obes 2010; 34 (01) 29-40
• 9 Martin RM, Smith GD, Frankel S, Gunnell D. Parents' growth in childhood and the birth weight of their offspring. Epidemiology 2004; 15 (03) 308-316
• 10 Fleten C, Nystad W, Stigum H. et al. Parent-offspring body mass index associations in the Norwegian Mother and Child Cohort Study: a family-based approach to studying the role of the intrauterine environment in childhood adiposity. Am J Epidemiol 2012; 176 (02) 83-92
• 11 Linabery AM, Nahhas RW, Johnson W. et al. Stronger influence of maternal than paternal obesity on infant and early childhood body mass index: the Fels Longitudinal Study. Pediatr Obes 2013; 8 (03) 159-169
• 12 Reynolds RM, Osmond C, Phillips DI, Godfrey KM. Maternal BMI, parity, and pregnancy weight gain: influences on offspring adiposity in young adulthood. J Clin Endocrinol Metab 2010; 95 (12) 5365-5369
• 13 Koletzko B, von Kries R, Closa R. et al. Can infant feeding choices modulate later obesity risk?. Am J Clin Nutr 2009; 89 (05) 1502S-1508S
• 14 Arenz S, Rückerl R, Koletzko B, von Kries R. Breast-feeding and childhood obesity–a systematic review. Int J Obes Relat Metab Disord 2004; 28 (10) 1247-1256
• 15 Patel R, Martin RM, Kramer MS. et al. Familial associations of adiposity: findings from a cross-sectional study of 12,181 parental-offspring trios from Belarus. PLoS One 2011; 6 (01) e14607
• 16 Walsh JM, McGowan CA, Mahony R, Foley ME, McAuliffe FM. Low glycaemic index diet in pregnancy to prevent macrosomia (ROLO study): randomised control trial. BMJ 2012; 345: e5605
• 17 Donnelly JM, Walsh JM, Byrne J, Molloy EJ, McAuliffe FM. Impact of maternal diet on neonatal anthropometry: a randomized controlled trial. Pediatr Obes 2015; 10 (01) 52-56
• 18 Foote JM, Brady LH, Burke AL. et al. Development of an evidence-based clinical practice guideline on linear growth measurement of children. J Pediatr Nurs 2011; 26 (04) 312-324
• 19 Bartram JL, Rigby AS, Baxter PS. The “Lasso-o” tape: stretchability and observer variability in head circumference measurement. Arch Dis Child 2005; 90 (08) 820-821
• 20 Control CfD. National Health and Nutrition Examination Survey. 2007 https://www.cdc.gov/nchs/data/nhanes/nhanes_07_08/manual_an.pdf
• 21 control Cfd. National Health and Nutrition Examination Survery III. 1988 https://wwwn.cdc.gov/nchs/data/nhanes3/manuals/anthro.pdf
• 22 Gillman MW, Rich-Edwards JW, Huh S. et al. Maternal corticotropin-releasing hormone levels during pregnancy and offspring adiposity. Obesity (Silver Spring) 2006; 14 (09) 1647-1653
• 23 Mokha JS, Srinivasan SR, Dasmahapatra P. et al. Utility of waist-to-height ratio in assessing the status of central obesity and related cardiometabolic risk profile among normal weight and overweight/obese children: the Bogalusa Heart Study. BMC Pediatr 2010; 10: 73
• 24 Liem ET, van Buuren S, Sauer PJ, Jaspers M, Stolk RP, Reijneveld SA. Growth during infancy and childhood, and adiposity at age 16 years: ages 2 to 7 years are pivotal. J Pediatr 2013; 162 (02) 287-92.e2
• 25 Lagström H, Hakanen M, Niinikoski H. et al. Growth patterns and obesity development in overweight or normal-weight 13-year-old adolescents: the STRIP study. Pediatrics 2008; 122 (04) e876-e883
• 26 De Kroon ML, Renders CM, Van Wouwe JP, Van Buuren S, Hirasing RA. The Terneuzen birth cohort: BMI changes between 2 and 6 years correlate strongest with adult overweight. PLoS One 2010; 5 (02) e9155
• 27 de Kroon ML, Renders CM, van Wouwe JP, van Buuren S, Hirasing RA. The Terneuzen Birth Cohort: BMI change between 2 and 6 years is most predictive of adult cardiometabolic risk. PLoS One 2010; 5 (11) e13966
• 28 Donkin I, Versteyhe S, Ingerslev LR. et al. Obesity and bariatric surgery drive epigenetic variation of spermatozoa in humans. Cell Metab 2016; 23 (02) 369-378
• 29 Karakosta P, Georgiou V, Fthenou E. et al. Maternal weight status, cord blood leptin and fetal growth: a prospective mother-child cohort study (Rhea study). Paediatr Perinat Epidemiol 2013; 27 (05) 461-471
• 30 Boeke CE, Oken E, Kleinman KP, Rifas-Shiman SL, Taveras EM, Gillman MW. Correlations among adiposity measures in school-aged children. BMC Pediatr 2013; 13: 99