Synlett 2024; 35(13): 1569-1571
DOI: 10.1055/s-0041-1738458
letter

Radiosynthesis of α-[18F]Fluoroamides with [18F]AgF

Kehao Gong
a   Institute of Radiation Medicine, Fudan University, Xietu Road 2094, Shanghai 200032, P. R. of China
,
Zhengxu Yin
b   School of Basic Medical Sciences, Guizhou Medical University, Guiyang 550025, P. R. of China
,
Pengfei Song
a   Institute of Radiation Medicine, Fudan University, Xietu Road 2094, Shanghai 200032, P. R. of China
,
Bo Xu
c   College of Chemistry and Chemical Engineering, Donghua University, North Renmin Road 2999, Shanghai 201620, P. R. of China
,
Junbin Han
a   Institute of Radiation Medicine, Fudan University, Xietu Road 2094, Shanghai 200032, P. R. of China
› Author Affiliations

We are grateful to the National Natural Science Foundation of China (NSFC 22001041 and 22171050) and the Shanghai Municipal Health Commission (GWV-11.1-40). B.X. is thankful to the National Natural Science Foundation of China (NSFC 22071022).


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Abstract

A silver-promoted nucleophilic radiofluorination of α-bromoamides has been developed for the radiosynthesis of α-[18F]fluoroamides. The reaction conditions are straightforward and compatible with primary, secondary, and tertiary α-bromoamides. Furthermore, the methodology has been successfully applied to the synthesis of bioactive radiotracers with good radiochemical conversion (RCC) and radiochemical yield (RCY).

Supporting Information



Publication History

Received: 06 October 2023

Accepted after revision: 27 November 2023

Article published online:
15 January 2024

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