Synthesis of 2-Arylbenzothiazoles from Nitrobenzenes, Benzylamines, and Elemental Sulfur via Redox Cyclization

Abstract

A sustainable advanced synthetic method was developed based on redox cyclization for the synthesis of 2-arylbenzothiazoles in good to excellent yields from readily available nitrobenzenes, benzylamines, and elemental sulfur without the use of transition-metal catalysts. This method is remarkable: nitro group reduction, a benzylamine redox reaction, sulfuration, condensation, and cyclization, all proceed in a single step to generate a heterocycle. It is also highly atom-economical and does not require any external oxidizing or reducing agents.

Key words

redox cyclization - benzothiazoles - nitrobenzenes - benzylamines - elemental sulfur - atom-economical

Publikationsverlauf

Eingereicht: 16. November 2021

Angenommen nach Revision: 14. Dezember 2021

Artikel online veröffentlicht:
18. Januar 2022

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