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Synfacts 2022; 18(06): 0691
DOI: 10.1055/s-0041-1737583
DOI: 10.1055/s-0041-1737583
Peptide Chemistry
Dipeptide Synthesis by Two-Component Organocatalysis
Handoko,
Panigrahi NR,
Arora PS.
*
New York University, USA
Two-Component Redox Organocatalyst for Peptide Bond Formation.
J. Am. Chem. Soc. 2022;
144: 3637-3643
DOI: 10.1021/jacs.1c12798.
Two-Component Redox Organocatalyst for Peptide Bond Formation.
J. Am. Chem. Soc. 2022;
144: 3637-3643
DOI: 10.1021/jacs.1c12798.
Significance
Catalytic peptide-bond formation is an important process in providing effective and economical systems for use in the industrial and pharmaceutical fields. The authors have developed a redox organocatalyst system for the formation of peptide bonds.
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Comment
The two-component catalytic process provides versatility in dipeptide syntheses. The authors propose a mechanism consisting of a reductant-driven phosphine cycle and an oxidant-driven selenium cycle.
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Publication History
Article published online:
17 May 2022
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