Synthesis 2022; 54(10): 2464-2472
DOI: 10.1055/s-0041-1737337
paper

Nickel-Catalyzed Regioselective Thiolation of Anilides with Thiols

Ebrahim Kianmehr
a   School of Chemistry, College of Science, University of Tehran, Tehran 1417614411, Iran
,
Fatemeh Doraghi
a   School of Chemistry, College of Science, University of Tehran, Tehran 1417614411, Iran
,
Alireza Foroumadi
b   Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 1417614411, Iran
› Institutsangaben

We gratefully acknowledge the financial support of the University of Tehran and the Iran National Science Foundation (INSF, no. 99002277).


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Abstract

An efficient method for direct thiolation of anilides with thiols using NiCl2·6H2O as the catalyst is developed. Using this method, the desired products were successfully synthesized in moderate to good yields. Initial mechanistic studies suggest that this reaction proceeds through a radical pathway.

Supporting Information



Publikationsverlauf

Eingereicht: 04. August 2021

Angenommen nach Revision: 06. Dezember 2021

Artikel online veröffentlicht:
16. Februar 2022

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