Introduction to Spatial Anion Control for Direct C–H Arylation

Jyoti Dhankhar; Ilija Čorić

doi:10.1055/s-0040-1719860

Synlett, Inhaltsverzeichnis

Synlett 2022; 33(06): 503-512
DOI: 10.1055/s-0040-1719860

synpacts

Introduction to Spatial Anion Control for Direct C–H Arylation

Jyoti Dhankhar

,

Ilija Čorić ∗

Abstract

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Abstract

C–H activation of functionally rich molecules without the need for directing groups promises shorter organic syntheses and late-stage diversification of molecules for drug discovery. We highlight recent examples of palladium-catalyzed nondirected functionalization of C–H bonds in arenes as limiting substrates with a focus on the development of the concept of spatial anion control for direct C–H arylation.

1 C–H Activation and the CMD Mechanism

2 Nondirected C–H Functionalizations of Arenes as Limiting Substrates

3 Nondirected C–H Arylation

4 Spatial Anion Control for Direct C–H Arylation

5 Coordination Chemistry with Spatial Anion Control

6 Conclusion

Key words

C–H activation - concerted metalation-deprotonation - CMD - C–H arylation - spatial anion control - palladium

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Referenzen

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