Efficacy of Circumferential Intensive Phototherapy in Treating Neonatal Hyperbilirubinemia: A Pilot Study

Abstract

Objective The present study was aimed at developing a circumferential phototherapy unit using 3M reflective materials in the double-sided phototherapy unit and investigating its efficacy in treating neonatal hyperbilirubinemia.

Study Design Forty-two infants with neonatal hyperbilirubinemia were selected from our hospital; they were randomly divided into control (n = 21) and experimental groups (n = 21). The experimental group was treated with the circumferential phototherapy unit, while the control group was treated with an ordinary phototherapy unit.

Results No significant differences were noted between the two groups in the levels of transcutaneous bilirubin before phototherapy (p > 0.05). After 12 hours of phototherapy, the value of transcutaneous bilirubin decreased significantly in the experimental group compared with that of the control group (p < 0.05). Additionally, the two groups did not exhibit any significant difference in the side effects (p > 0.05).

Conclusion Our results indicated that the circumferential phototherapy unit was more effective than the ordinary phototherapy unit in treating neonatal hyperbilirubinemia.

Key Points

• A circumferential phototherapy unit was developed using 3M reflective materials.

• The circumferential phototherapy unit was more effective than the ordinary.

• The two groups did not exhibit any significant difference in the side effects.

Keywords

circumferential phototherapy - neonatal hyperbilirubinemia - transcutaneous bilirubin - newborn

Note

The study was approved by the ethics committee of Hangzhou Women's Hospital. Verbal and written informed consent was obtained from the infants' parents. The clinical registration number was ChiCTR2000032551.

Publication History

Received: 27 March 2020

Accepted: 03 August 2020

Article published online:
19 September 2020

• References

• 1 Lin CH, Yang HC, Cheng CS, Yen CE. Effects of infant massage on jaundiced neonates undergoing phototherapy. Ital J Pediatr 2015; 41: 94
• 2 Mir SE, van der Geest BAM, Been JV. Management of neonatal jaundice in low- and lower-middle-income countries. BMJ Paediatr Open 2019; 3 (01) e000408
• 3 Itoh S, Okada H, Kuboi T, Kusaka T. Phototherapy for neonatal hyperbilirubinemia. Pediatr Int (Roma) 2017; 59 (09) 959-966
• 4 Wolf MF, Childers J, Gray KD. et al. Exchange transfusion safety and outcomes in neonatal hyperbilirubinemia. J Perinatol 2020;
• 5 Boskabadi H, Rakhshanizadeh F, Zakerihamidi M. Evaluation of maternal risk factors in neonatal hyperbilirubinemia. Arch Iran Med 2020; 23 (02) 128-140
• 6 Muchowski KE. Evaluation and treatment of neonatal hyperbilirubinemia. Am Fam Physician 2014; 89 (11) 873-878
• 7 Cremer RJ, Perryman PW, Richards DH. Influence of light on the hyperbilirubinaemia of infants. Lancet 1958; 1 (7030): 1094-1097
• 8 Kusaka T. Effectiveness of green light phototherapy for neonatal hyperbilirubinemia. Pediatr Int (Roma) 2019; 61 (08) 747
• 9 Onishi S, Isobe K, Itoh S. et al. Metabolism of bilirubin and its photoisomers in newborn infants during phototherapy. J Biochem 1986; 100 (03) 789-795
• 10 Kuboi T, Kusaka T, Okada H. et al. Green light-emitting diode phototherapy for neonatal hyperbilirubinemia: Randomized controlled trial. Pediatr Int (Roma) 2019; 61 (05) 465-470
• 11 Donneborg ML, Vandborg PK, Hansen BM, Rodrigo-Domingo M, Ebbesen F. Double versus single intensive phototherapy with LEDs in treatment of neonatal hyperbilirubinemia. J Perinatol 2018; 38 (02) 154-158
• 12 Ebbesen F, Hansen TWR, Maisels MJ. Update on phototherapy in jaundiced neonates. Curr Pediatr Rev 2017; 13 (03) 176-180
• 13 Boonyarittipong P, Kriangburapa W, Booranavanich K. Effectiveness of double-surface intensive phototherapy versus single-surface intensive phototherapy for neonatal hyperbilirubinemia. J Med Assoc Thai 2008; 91 (01) 50-55
• 14 Greco C, Arnolda G, Boo NY. et al. Neonatal jaundice in low- and middle-income countries: lessons and future directions from the 2015 Don Ostrow Trieste Yellow Retreat. Neonatology 2016; 110 (03) 172-180
• 15 Lee Wan Fei S, Chew KS, Pawi S. et al. Systematic review of the effect of reflective materials around a phototherapy unit on bilirubin reduction among neonates with physiologic jaundice in developing countries. J Obstet Gynecol Neonatal Nurs 2018; 47 (06) 795-802
• 16 Wells C, Ahmed A, Musser A. Strategies for neonatal hyperbilirubinemia: a literature review. MCN Am J Matern Child Nurs 2013; 38 (06) 377-382 , quiz 383–384
• 17 Zeng J, Wang SJ, Li YM. et al. Yinzhihuang oral liquid in the treatment of neonatal jaundice: a meta-analysis. Pharm Biol 2017; 55 (01) 554-559
• 18 Murki S, Kumar P. Blood exchange transfusion for infants with severe neonatal hyperbilirubinemia. Semin Perinatol 2011; 35 (03) 175-184