Diaphragmatic Hernia following Pediatric Liver Transplantation: An Underappreciated Complication Prone to Recur

Lea Sibylle Waldron; Miriam Cortes Cerisuelo; Denise Lo; Blayne Amir Sayed; Hector Vilca-Melendez; Joseph Magliocca; Eberhard Lurz; Ulrich Baumann; Florian W. R. Vondran; Nicolas Richter; Dietrich von Schweinitz; Markus Guba; Oliver J. Muensterer; Michael Berger

doi:10.1055/s-0040-1716882

European Journal of Pediatric Surgery, Table of Contents

Eur J Pediatr Surg 2021; 31(05): 396-406
DOI: 10.1055/s-0040-1716882

Original Article

Diaphragmatic Hernia following Pediatric Liver Transplantation: An Underappreciated Complication Prone to Recur

Lea Sibylle Waldron

¹Department of Pediatric Surgery, University Medical Center of the Johannes Gutenberg University, Mainz, Germany

²Department of Pediatrics, Hospital of the Philipps-University Marburg, Marburg, Germany

,

Miriam Cortes Cerisuelo

³Liver Transplant Surgery, Institute of Liver Studies, King's College Hospital, National Health Service Foundation Trust, London, United Kingdom

,

Denise Lo

⁴Emory Transplant Center, Emory University, Atlanta, United States

,

Blayne Amir Sayed

⁵Department of Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada

,

Hector Vilca-Melendez

³Liver Transplant Surgery, Institute of Liver Studies, King's College Hospital, National Health Service Foundation Trust, London, United Kingdom

,

Joseph Magliocca

⁴Emory Transplant Center, Emory University, Atlanta, United States

,

Eberhard Lurz

⁶Division of Pediatric Gastroenterology, Hepatology and Nutrition, Dr. von Hauner Children’s Hospital, Ludwig-Maximillians-University, Munich, Germany

,

Ulrich Baumann

⁷Department of Pediatric Gastroenterology, Hannover Medical School, Hannover, Germany

⁸Institute for Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom

,

Florian W. R. Vondran

⁹Department for General, Visceral and Transplant Surgery, Hannover Medical School, Hannover, Niedersachsen, Germany

,

Nicolas Richter

⁹Department for General, Visceral and Transplant Surgery, Hannover Medical School, Hannover, Niedersachsen, Germany

,

Dietrich von Schweinitz

¹⁰Department of Pediatric Surgery, Dr. von Hauner Children’s Hospital, Ludwig-Maximillians-University, Munich, Germany

,

Markus Guba

¹¹Department of General, Visceral and Transplant Surgery, University Hospital, Ludwig-Maximilians-University, Munich, Germany

,

Oliver J. Muensterer

¹Department of Pediatric Surgery, University Medical Center of the Johannes Gutenberg University, Mainz, Germany

¹⁰Department of Pediatric Surgery, Dr. von Hauner Children’s Hospital, Ludwig-Maximillians-University, Munich, Germany

,

Michael Berger

¹⁰Department of Pediatric Surgery, Dr. von Hauner Children’s Hospital, Ludwig-Maximillians-University, Munich, Germany

› Author Affiliations

Abstract

Introduction Postoperative diaphragmatic hernia (DH) is a rare but potentially life-threatening complication following pediatric liver transplantation (LT). In the current literature, a total of 49 such hernias have been reported in 17 case series. We present eight additional cases, three of which reoccurred after surgical correction, and review the current literature with a focus on recurrence.

Materials and Methods The study sample included children (<18 years of age) who underwent LT between June 2013 and June 2020 at five large transplant centers and who subsequently presented with DH. During the study period, a total of 907 LT was performed. Eight DH were recognized, and risk factors were analyzed.

Results For the eight children with DH, the mean age at LT was 28.0 (5–132) months. All patients with a DH received left lateral segment split grafts except one, who received a full left lobe. The mean weight at time of LT was 11.8 (6.6–34) kg. Two patients had a primary abdominal muscle closure, and six had a temporary silastic mesh closure. All eight children presented with a right posterolateral DH. The small bowel was herniated in the majority of cases. Symptoms reported included nausea, vomiting, and respiratory distress. Two patients were asymptomatic, and discovery was incidental. All patients underwent prompt primary surgical repair. Three DH hernias (37.5%) recurred despite successful surgical correction.

Conclusion DH following liver transplant with technical variant grafts may be underreported and is prone to recur despite surgical correction. A better understanding of the pathophysiology and more thorough reporting may help increase awareness. Early detection and prompt surgical management are the cornerstones of a successful outcome.

Keywords

pediatric liver transplantation - diaphragmatic hernia - liver surgery

Full Text

References

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