Decarboxylative Bromination of Heteroarenes: Initial Mechanistic Insights

Abstract

After an initial report from our laboratory describing metal-free decarboxylative halogenation of various azaheteroarenes, we set out to investigate the possible mechanism by which this chemistry occurs. Evidence from this mechanistic investigation suggests that this chemistry occurs via a radical pathway, with ¹H NMR studies suggesting that the acidic substrates activate NBS.

Key words

decarboxylation - halogenation - reaction mechanism - bromosuccinimide - azahetarenes

• References and Notes

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