A novel and efficient route for the synthesis of 3-sulfonylchroman-4-ones from α-sulfonyl
o-hydroxyacetophenones with methyl sulfoxides via a MeONH2·HCl-mediated sequential methylenation/ conjugate addition is described. Plausible
reaction mechanisms are proposed and discussed. Various reaction conditions for this
novel, one-pot, environmentally friendly conversion were investigated.
Key words
chroman-4-ones -
o-hydroxyacetophenones - methylenation - methyl sulfoxides - sulfonyl compounds