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Synfacts 2021; 17(05): 0579
DOI: 10.1055/s-0040-1706191
DOI: 10.1055/s-0040-1706191
Peptide Chemistry
Catalytic Intramolecular C–H Alkylation for the Synthesis of Peptide Macrocycles
Hu X,
Chen X,
Li B,
He G,
Chen G.
*
Nankai University, Tianjin, P. R. of China
Construction of Peptide Macrocycles via Radical-Mediated Intramolecular C–H Alkylations.
Org. Lett. 2021;
23: 716-721
DOI: 10.1021/acs.orglett.0c03940.
Construction of Peptide Macrocycles via Radical-Mediated Intramolecular C–H Alkylations.
Org. Lett. 2021;
23: 716-721
DOI: 10.1021/acs.orglett.0c03940.
Key words
photocatalysis - copper catalysis - iridium catalysis - peptide macrocycles - C–H alkylation - macrocyclization
Significance
Peptide macrocycles provide an important platform for drug discovery. The authors have developed intramolecular C–H alkylations under blue LED irradiation for the macrocyclization of peptides.
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Comment
Copper- or iridium-catalyzed intramolecular C–H alkylations were successfully promoted by blue LED irradiation. The desired peptide macrocycles were obtained in moderate yields.
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Publication History
Article published online:
20 April 2021
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