Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2021; 17(05): 0587
DOI: 10.1055/s-0040-1706184
DOI: 10.1055/s-0040-1706184
Peptide Chemistry
Thiopyridone-Derived Reagents for Peptide Coupling Reactions
Bailén MA,
Chinchilla R,
Dodsworth DJ,
Nájera C.
*
Universidad de Alicante, Spain
2-Mercaptopyridone 1-Oxide-Based Uronium Salts: New Peptide Coupling Reagents.
J. Org. Chem. 1999;
64: 8936-8939
DOI: 10.1021/jo990660q
2-Mercaptopyridone 1-Oxide-Based Uronium Salts: New Peptide Coupling Reagents.
J. Org. Chem. 1999;
64: 8936-8939
DOI: 10.1021/jo990660q
Significance
Peptide coupling reagents are extremely important in peptide synthesis. In 1999, Nájera and co-workers reported a method for synthesizing thiopyridone-derived uronium salts as coupling reagents. The reagents were prepared from cheap starting materials, making them more economical than conventional coupling reagents such as HOBt.
#
Comment
By using the thiopyridone-derived reagents as coupling reagents, various dipeptides were synthesized in moderate to excellent yields.
#
#
Publication History
Article published online:
20 April 2021
© 2021. Thieme. All rights reserved
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany