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Synfacts 2021; 17(03): 0347
DOI: 10.1055/s-0040-1706129
DOI: 10.1055/s-0040-1706129
Peptide Chemistry
Rhodium-Catalyzed Formation of Disulfide Bonds in Water
Arisawa M,
*,
Fukumoto K,
Yamaguchi M.
Tohoku University, Sendai, Japan
Rhodium-Catalyzed Oxidation of Unprotected Peptide Thiols to Disulfides with Oxygen in Water.
ACS Catal. 2020;
10: 15060-15064
DOI: 10.1021/acscatal.0c04799.
Rhodium-Catalyzed Oxidation of Unprotected Peptide Thiols to Disulfides with Oxygen in Water.
ACS Catal. 2020;
10: 15060-15064
DOI: 10.1021/acscatal.0c04799.
Significance
The disulfide bond is widely found in peptides and proteins, and it is important for the formation of the structures of proteins. The authors report a rhodium-catalyzed oxidation reaction to form disulfide bonds in water.
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Comment
Various peptide disulfides can be synthesized in water by using a rhodium(III) catalyst. No protecting groups are needed for these peptides in the reactions. The yields of the products are almost quantitative.
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Publication History
Article published online:
16 February 2021
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