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Synfacts 2021; 17(03): 0356
DOI: 10.1055/s-0040-1706128
DOI: 10.1055/s-0040-1706128
Peptide Chemistry
Peptides Synthesis by Using Nitrophenyl Esters
Authors
Bodánszky M.
*
Research Institute of the Pharmaceutical Industry, Budapest, Hungary
Synthesis of Peptides by Aminolysis of Nitrophenyl Esters.
Nature 1955;
175: 685-685
DOI: 10.1038/175685a0
Synthesis of Peptides by Aminolysis of Nitrophenyl Esters.
Nature 1955;
175: 685-685
DOI: 10.1038/175685a0
Significance
Peptide-bond formation is extremely important in peptide chemistry. In 1955, Bodánszky used active nitrophenyl esters to form peptide bonds. Before this work, only nonactive esters, such as methyl or ethyl esters, were used in peptide-bond formation.
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Comment
The author gave several examples dipeptide synthesis from active amino acid esters. Nitrophenyl esters gave much better results than thiophenyl esters.
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Publikationsverlauf
Artikel online veröffentlicht:
16. Februar 2021
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