J Knee Surg 2021; 34(11): 1205-1211
DOI: 10.1055/s-0040-1702165
Original Article

Physical Activity Mediates the Relationship between Gait Function and Fall Incidence after Total Knee Arthroplasty

1   Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Shogoin, Sakyo-ku, Kyoto, Japan
,
Shinichiro Sawano
2   Rehabilitation Units, Shiga University of Medical Science Hospital, Tsukinowa-cho, Seta, Otsu City, Shiga, Japan
,
Shoji Maegawa
2   Rehabilitation Units, Shiga University of Medical Science Hospital, Tsukinowa-cho, Seta, Otsu City, Shiga, Japan
,
Tome Ikezoe
1   Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Shogoin, Sakyo-ku, Kyoto, Japan
,
Noriaki Ichihashi
1   Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Shogoin, Sakyo-ku, Kyoto, Japan
› Author Affiliations

Abstract

The present study aims to examine (1) the preoperative factors that can predict postoperative falls, (2) whether postoperative physical activity (PA) mediates the relationship between fall incidence and gait function, and (3) whether postoperative PA levels are associated with fall risk in total knee arthroplasty (TKA) patients. Ninety-six patients (mean age: 72.0 ± 6.1 years) who were observed postoperatively for 6 months were selected. Timed up and go (TUG) was assessed as an indicator of gait function. Fall incidence and PA were investigated for 6 months post-TKA. The body mass index, history of preoperative falls, knee pain, knee extensor strength, range of motion in knee flexion, and modified gait efficacy scale were evaluated. Additionally, postoperative PA levels were categorized into three groups—low: <3,000, moderate: 3,000 to 4,000, and high: ≥4,000 steps/day. The relative fall incidence rate was calculated according to the total number of falls normalized for every 1,000 steps/day for 6 months postoperatively. Twenty-five (26.0%) of the 96 patients had at least one fall. The TUG, knee pain, and knee extensor strength were identified preoperatively as significant variables affecting postoperative falls. The mediated effects model revealed that postoperative fall incidence was predicted by preoperative TUG and postoperative PA. Postoperative PA was significantly associated with preoperative TUG. Moreover, both the preoperative TUG and postoperative PA were selected as significant variables for predicting fall incidence. Thus, postoperative PA mediates the relationship between gait function and fall incidence after TKA. Furthermore, the relative fall incidence rate associated with a low PA level was significantly higher than that associated with moderate and high PA levels. In conclusion, preoperative assessments of TUG performance, muscle strength, and knee pain were effective in predicting fall risk. Additionally, an increase in PA could contribute to reducing fall risk in TKA patients. Therefore, our results suggest that preoperative screening for fall predictors and managing postoperative PA could reduce the fall incidence in TKA patients.



Publication History

Received: 13 November 2018

Accepted: 07 January 2020

Article published online:
04 March 2020

© 2020. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 
  • References

  • 1 George LK, Ruiz Jr D, Sloan FA. The effects of total knee arthroplasty on physical functioning in the older population. Arthritis Rheum 2008; 58 (10) 3166-3171
  • 2 Naili JE, Wretenberg P, Lindgren V, Iversen MD, Hedström M, Broström EW. Improved knee biomechanics among patients reporting a good outcome in knee-related quality of life one year after total knee arthroplasty. BMC Musculoskelet Disord 2017; 18 (01) 122
  • 3 Matsumoto H, Okuno M, Nakamura T, Yamamoto K, Hagino H. Fall incidence and risk factors in patients after total knee arthroplasty. Arch Orthop Trauma Surg 2012; 132 (04) 555-563
  • 4 Swinkels A, Newman JH, Allain TJ. A prospective observational study of falling before and after knee replacement surgery. Age Ageing 2009; 38 (02) 175-181
  • 5 Levinger P, Menz HB, Wee E, Feller JA, Bartlett JR, Bergman NR. Physiological risk factors for falls in people with knee osteoarthritis before and early after knee replacement surgery. Knee Surg Sports Traumatol Arthrosc 2011; 19 (07) 1082-1089
  • 6 Chan ACM, Jehu DA, Pang MYC. Falls after total knee arthroplasty: frequency, circumstances, and associated factors-a prospective cohort study. Phys Ther 2018; 98 (09) 767-778
  • 7 Kennedy DM, Stratford PW, Riddle DL, Hanna SE, Gollish JD. Assessing recovery and establishing prognosis following total knee arthroplasty. Phys Ther 2008; 88 (01) 22-32
  • 8 Bade MJ, Kohrt WM, Stevens-Lapsley JE. Outcomes before and after total knee arthroplasty compared to healthy adults. J Orthop Sports Phys Ther 2010; 40 (09) 559-567
  • 9 Schoene D, Wu SM, Mikolaizak AS. et al. Discriminative ability and predictive validity of the timed up and go test in identifying older people who fall: systematic review and meta-analysis. J Am Geriatr Soc 2013; 61 (02) 202-208
  • 10 Swinkels A, Allain TJ. Physical performance tests, self-reported outcomes, and accidental falls before and after total knee arthroplasty: an exploratory study. Physiother Theory Pract 2013; 29 (06) 432-442
  • 11 Mizner RL, Petterson SC, Stevens JE, Axe MJ, Snyder-Mackler L. Preoperative quadriceps strength predicts functional ability one year after total knee arthroplasty. J Rheumatol 2005; 32 (08) 1533-1539
  • 12 Hiyama Y, Wada O, Nakakita S, Mizuno K. Factors affecting mobility after knee arthroplasty. J Knee Surg 2017; 30 (04) 304-308
  • 13 Pelt CE, Anderson AW, Anderson MB, Van Dine C, Peters CL. Postoperative falls after total knee arthroplasty in patients with a femoral nerve catheter: can we reduce the incidence?. J Arthroplasty 2014; 29 (06) 1154-1157
  • 14 Riddle DL, Golladay GJ. Preoperative risk factors for postoperative falls in persons undergoing hip or knee arthroplasty: a longitudinal study of data from the osteoarthritis initiative. Arch Phys Med Rehabil 2018; 99 (05) 967-972
  • 15 Si HB, Zeng Y, Zhong J. et al. The effect of primary total knee arthroplasty on the incidence of falls and balance-related functions in patients with osteoarthritis. Sci Rep 2017; 7 (01) 16583
  • 16 Tsonga T, Michalopoulou M, Kapetanakis S. et al. Reduction of falls and factors affecting falls a year after total knee arthroplasty in elderly patients with severe knee osteoarthritis. Open Orthop J 2016; 10: 522-531
  • 17 Taniguchi M, Sawano S, Kugo M, Maegawa S, Kawasaki T, Ichihashi N. Physical activity promotes gait improvement in patients with total knee arthroplasty. J Arthroplasty 2016; 31 (05) 984-988
  • 18 Klenk J, Kerse N, Rapp K. et al; ActiFE Study Group. Physical activity and different concepts of fall risk estimation in older people--results of the ActiFE-Ulm study. PLoS One 2015; 10 (06) e0129098
  • 19 Jefferis BJ, Merom D, Sartini C. et al. Physical activity and falls in older men: the critical role of mobility limitations. Med Sci Sports Exerc 2015; 47 (10) 2119-2128
  • 20 Chan BK, Marshall LM, Winters KM, Faulkner KA, Schwartz AV, Orwoll ES. Incident fall risk and physical activity and physical performance among older men: the osteoporotic fractures in men study. Am J Epidemiol 2007; 165 (06) 696-703
  • 21 Brach JS, Simonsick EM, Kritchevsky S, Yaffe K, Newman AB. Health, Aging and Body Composition Study Research Group. The association between physical function and lifestyle activity and exercise in the health, aging and body composition study. J Am Geriatr Soc 2004; 52 (04) 502-509
  • 22 Ogilvie D, Foster CE, Rothnie H. et al; Scottish Physical Activity Research Collaboration. Interventions to promote walking: systematic review. BMJ 2007; 334 (7605): 1204
  • 23 O'Loughlin JL, Robitaille Y, Boivin JF, Suissa S. Incidence of and risk factors for falls and injurious falls among the community-dwelling elderly. Am J Epidemiol 1993; 137 (03) 342-354
  • 24 Peduzzi P, Concato J, Kemper E, Holford TR, Feinstein AR. A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol 1996; 49 (12) 1373-1379
  • 25 Buchner DM, Hornbrook MC, Kutner NG. et al. Development of the common data base for the FICSIT trials. J Am Geriatr Soc 1993; 41 (03) 297-308
  • 26 Newell AM, VanSwearingen JM, Hile E, Brach JS. The modified gait efficacy scale: establishing the psychometric properties in older adults. Phys Ther 2012; 92 (02) 318-328
  • 27 Baron RM, Kenny DA. The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol 1986; 51 (06) 1173-1182
  • 28 Tsonga T, Kapetanakis S, Papadopoulos C. et al. Evaluation of improvement in quality of life and physical activity after total knee arthroplasty in Greek elderly women. Open Orthop J 2011; 5: 343-347
  • 29 Schmalzried TP, Szuszczewicz ES, Northfield MR. et al. Quantitative assessment of walking activity after total hip or knee replacement. J Bone Joint Surg Am 1998; 80 (01) 54-59
  • 30 Tonelli SM, Rakel BA, Cooper NA, Angstom WL, Sluka KA. Women with knee osteoarthritis have more pain and poorer function than men, but similar physical activity prior to total knee replacement. Biol Sex Differ 2011; 2: 12