J Knee Surg 2021; 34(10): 1042-1047
DOI: 10.1055/s-0040-1701449
Original Article

Opioid Naive Surgeons and Opioid-Tolerant Patients: Can Education Alter Prescribing Patterns to Total Knee Arthroplasty Patients?

1   Department of Orthopaedic Surgery, University of Chicago, Chicago, Illinois
,
David C. Landy
1   Department of Orthopaedic Surgery, University of Chicago, Chicago, Illinois
,
Alexander T. Bradley
1   Department of Orthopaedic Surgery, University of Chicago, Chicago, Illinois
,
Bryan Scott
1   Department of Orthopaedic Surgery, University of Chicago, Chicago, Illinois
,
John Curran
2   Pritzker School of Medicine, University of Chicago, Chicago, Illinois
,
Shwetha Devanagondi
3   Medicine Analytics Core, University of Chicago, Chicago, Illinois
,
Tessa Balach
1   Department of Orthopaedic Surgery, University of Chicago, Chicago, Illinois
,
Megan Conti Mica
1   Department of Orthopaedic Surgery, University of Chicago, Chicago, Illinois
› Author Affiliations
Funding None.

Abstract

Patterns of opioid overprescribing following arthroplasty likely developed given that poor pain control can diminish patient satisfaction, delay disposition, and lead to complications. Recently, interventions promoting responsible pain management have been described, however, most of the existing literature focuses on opioid naive patients. The aim of this study was to describe the effect of an educational intervention on opioid prescribing for opioid-tolerant patients undergoing primary total knee arthroplasty (TKA). As the start to a quality improvement initiative to reduce opioid overprescribing, a departmental grand rounds was conducted. Prescribing data, for the year before and after this intervention, were retrospectively collected for all opioid-tolerant patients undergoing primary TKA. Opioid prescribing data were standardized to mean morphine milligram equivalents (MME). Segmented time series regression was utilized to estimate the change in opioid prescribing associated with the intervention. A total of 508 opioid-tolerant patients underwent TKA at our institution during the study period. The intervention was associated with a statistically significant decrease of 468 mean MME (23%) from 2,062 to 1,594 (p = 0.005) in TKA patients. This study demonstrates that an educational intervention is associated with decreased opioid prescribing among opioid-tolerant TKA patients. While the effective management of these patients is challenging, surgeon education should be a key focus to optimizing their care.

Supplementary Material



Publication History

Received: 29 May 2019

Accepted: 13 December 2019

Article published online:
04 March 2020

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  • References

  • 1 Vivolo-Kantor AM, Seth P, Gladden RM. et al. Vital signs: trends in emergency department visits for suspected opioid overdoses - United States, July 2016-September 2017. MMWR Morb Mortal Wkly Rep 2018; 67 (09) 279-285
  • 2 Wilkerson RG, Kim HK, Windsor TA, Thomas AM, Mareiniss DP. Emergency Medicine Clinics of North America. Emergency Medicine Clinics of North America 2016;34(02). doi: 10.1016/j.emc.2015.11.002
  • 3 Morris BJ, Mir HR. The opioid epidemic: impact on orthopaedic surgery. J Am Acad Orthop Surg 2015; 23 (05) 267-271
  • 4 Bedard NA, Pugely AJ, Westermann RW, Duchman KR, Glass NA, Callaghan JJ. Opioid use after total knee arthroplasty: trends and risk factors for prolonged use. J Arthroplasty 2017; 32 (08) 2390-2394
  • 5 Wright EA, Katz JN, Abrams S, Solomon DH, Losina E. Trends in prescription of opioids from 2003-2009 in persons with knee osteoarthritis. Arthritis Care Res (Hoboken) 2014; 66 (10) 1489-1495
  • 6 Walid MS, Donahue SN, Darmohray DM, Hyer Jr. LA, Robinson Jr JS. The fifth vital sign--what does it mean?. Pain Pract 2008; 8 (06) 417-422
  • 7 Alter TH, Ilyas AM. A prospective randomized study analyzing preoperative opioid counseling in pain management after carpal tunnel release surgery. J Hand Surg Am 2017; 42 (10) 810-815
  • 8 Holman JE, Stoddard GJ, Horwitz DS, Higgins TF. The effect of preoperative counseling on duration of postoperative opiate use in orthopaedic trauma surgery: a surgeon-based comparative cohort study. J Orthop Trauma 2014; 28 (09) 502-506
  • 9 Earp BE, Silver JA, Mora AN, Blazar PE. Implementing a postoperative opioid-prescribing protocol significantly reduces the total morphine milligram equivalents prescribed. J Bone Joint Surg Am 2018; 100 (19) 1698-1703
  • 10 Donaldson SR, Harding AM, Taylor SE, Vally H, Greene SL. Evaluation of a targeted prescriber education intervention on emergency department discharge oxycodone prescribing. Emerg Med Australas 2017; 29 (04) 400-406
  • 11 Chen JH, Hom J, Richman I, Asch SM, Podchiyska T, Johansen NA. Effect of opioid prescribing guidelines in primary care. Medicine (Baltimore) 2016; 95 (35) e4760
  • 12 Stepan JG, Lovecchio FC, Premkumar A. et al. Development of an institutional opioid prescriber education program and opioid-prescribing guidelines: impact on prescribing practices. J Bone Joint Surg Am 2019; 101 (01) 5-13
  • 13 Weick J, Bawa H, Dirschl DR, Luu HH. Preoperative opioid use is associated with higher readmission and revision rates in total knee and total hip arthroplasty. J Bone Joint Surg Am 2018; 100 (14) 1171-1176
  • 14 Goesling J, Moser SE, Zaidi B. et al. Trends and predictors of opioid use after total knee and total hip arthroplasty. Pain 2016; 157 (06) 1259-1265
  • 15 American Academy of Orthopaedic Surgeons (AAOS). Opioid use, misuse, and abuse in orthopaedic practice. Accessed December 30, 2019 at: https://www.aaos.org/uploadedFiles/PreProduction/About/Opinion_Statements/advistmt/1045%20Opioid%20Use,%20Misuse,%20and%20Abuse%20in%20Practice.pdf
  • 16 Wagner AK, Soumerai SB, Zhang F, Ross-Degnan D. Segmented regression analysis of interrupted time series studies in medication use research. J Clin Pharm Ther 2002; 27 (04) 299-309
  • 17 McGreevy K, Bottros MM, Raja SN. Preventing chronic pain following acute pain: risk factors, preventive strategies, and their efficacy. Eur J Pain Suppl 2011; 5 (02) 365-372
  • 18 Bade MJ, Stevens-Lapsley JE. Early high-intensity rehabilitation following total knee arthroplasty improves outcomes. J Orthop Sport Phys Ther 2011; 41 (12) 932-941
  • 19 Chang AK, Bijur PE, Esses D, Barnaby DP, Baer J. Effect of a single dose of oral opioid and nonopioid analgesics on acute extremity pain in the emergency department: a randomized clinical trial. JAMA 2017; 318 (17) 1661-1667
  • 20 Krebs EE, Gravely A, Nugent S. et al. Effect of opioid vs nonopioid medications on pain-related function in patients with chronic back pain or hip or knee osteoarthritis pain: the SPACE randomized clinical trial. JAMA 2018; 319 (09) 872-882
  • 21 Zarling BJ, Yokhana SS, Herzog DT, Markel DC. Preoperative and postoperative opiate use by the arthroplasty patient. J Arthroplasty 2016; 31 (10) 2081-2084
  • 22 Jones CM, Campopiano M, Baldwin G, McCance-Katz E. National and state treatment need and capacity for opioid agonist medication-assisted treatment. Am J Public Health 2015; 105 (08) e55-e63
  • 23 Muhuri PK, Gfroerer JC, Davies MC. CBHSQ Data Review. Accessed December 30, 2019 at: https://www.ncbi.nlm.nih.gov/pubmed/27748090
  • 24 Sun EC, Darnall BD, Baker LC, Mackey S. Incidence of and risk factors for chronic opioid use among opioid-naive patients in the postoperative period. JAMA Intern Med 2016; 176 (09) 1286-1293
  • 25 Sabatino MJ, Kunkel ST, Ramkumar DB, Keeney BJ, Jevsevar DS. Excess opioid medication and variation in prescribing patterns following common orthopaedic procedures. J Bone Joint Surg Am 2018; 100 (Suppl. 03) 180-188
  • 26 Hannon CP, Calkins TE, Li J. et al. The James A. Rand young investigator's award: large opioid prescriptions are unnecessary after total joint arthroplasty: a randomized controlled trial. J Arthroplasty 2019; 34 (7S): S4-S10
  • 27 Howard R, Fry B, Gunaseelan V. et al. Association of opioid prescribing with opioid consumption after surgery in Michigan. JAMA Surg 2019; 154 (01) e184234
  • 28 Roberts K, Moser S, Schaffer N, Dubois K, Burmmett AM. Prescribing and consumption of opioids after primary, unilateral total hip and knee arthroplasty in opioid naive patients. J Arthroplasty 2019. Doi: 10.1016/j.arth.2019.08.036
  • 29 Stanek JJ, Renslow MA, Kalliainen LK. The effect of an educational program on opioid prescription patterns in hand surgery: a quality improvement program. J Hand Surg Am 2015; 40 (02) 341-346
  • 30 Wyles CC, Hevesi M, Trousdale ER. et al. The 2018 Chitranjan S. Ranawat, MD award: developing and implementing a novel institutional guideline strategy reduced postoperative opioid prescribing after TKA and THA. Clin Orthop Relat Res 2019; 477 (01) 104-113
  • 31 American Association of Hip and Knee Surgeons. Position statement: Opioid Use for the Treatment of Osteoarthritis of the Hip and Knee. Accessed December 30, 2019 at: http://www.aahks.org/position-statements/opioid-use-for-the-treatment-of-osteoarthritis-of-the-hip-and-knee/
  • 32 American Academy of Orthopaedic Surgeons (AAOS). Pain Relief Toolkit. Accessed December 30, 2019 at: http://www.aaos.org/Quality/PainReliefToolkit