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Synthesis 2020; 52(11): 1659-1665
DOI: 10.1055/s-0039-1691731
DOI: 10.1055/s-0039-1691731
paper
Cascade Reactions to Substituted 1H-Pyrrole-3-carbonitriles via Ligand-Free Palladium(II)-Catalyzed C(sp)–C(sp2) Coupling
This study was supported by the National Natural Science Foundation of China (No. 81602959 to J.S.), Natural Science Foundation of Zhejiang Province (LY18H300001), and Multiple Sclerosis National Research Institute, USA (to W.C.).Further Information
Publication History
Received: 26 November 2019
Accepted after revision: 08 January 2020
Publication Date:
25 February 2020 (online)
Abstract
An efficient and simple synthesis of substituted 1H-pyrrole-3-carbonitriles was developed. This reaction is a palladium(II)-catalyzed cascade of C(sp)–C(sp2) coupling followed by intramolecular C–N bond formation. The method can tolerate various substrates with satisfactory yields. Its ligand-free conditions and high efficiency make this method particularly attractive.
Key words
C–C coupling - palladium - ligand-free - cascade reactions - substituted 1H-pyrrole-3-carbonitrilesSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1691731.
- Supporting Information
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