Synfacts 2019; 15(08): 0950
DOI: 10.1055/s-0039-1690479
Peptide Chemistry
© Georg Thieme Verlag Stuttgart · New York

Azotide Ligands for Hetero-Diels–Alder Reactions

Hisashi Yamamoto
Tomohiro Hattori
Jacobsen CB, Nielsen DS, Meldal M. * Diness F. * University of Copenhagen, Denmark
Azotides as Modular Peptide-Based Ligands for Asymmetric Lewis Acid Catalysis.

J. Org. Chem. 2019;
84: 6940-6945
Further Information

Publication History

Publication Date:
18 July 2019 (online)



Azotides, which are abundantly found as scaffolds in natural products, are known to coordinate metal ions. The author report new azotide ligands for enantioselective Lewis acid catalysis.



The ligands were readily prepared from the chiral pool of amino acids and demonstrated enantioselectivity when used as ligands in a cobalt(II)-catalyzed hetero-Diels–Alder reaction.