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Synthesis 2019; 51(21): 4078-4084
DOI: 10.1055/s-0039-1690178
DOI: 10.1055/s-0039-1690178
paper
A Straightforward Conversion of Activated Amides and Haloalkanes into Esters under Transition-Metal-Free Cs2CO3/DMAP Conditions
The authors gratefully acknowledge the support of Science and Technology Planning Project of Guangdong Province (2017A010103017), Special Innovation Projects of Common Universities in Guangdong Province (20178S0182), National Natural Science Foundation of China (21272080).Further Information
Publication History
Received: 03 April 2019
Accepted after revision: 24 July 2019
Publication Date:
14 August 2019 (online)
Abstract
The esterification of activated amides, N-acylsaccharins, under transition-metal-free conditions with good functional group tolerance has been developed, resulting in C–N cleavage leading to efficient synthesis of a variety of esters in moderate to good yields. This work demonstrates that esterification may proceed by using simple N-acylsaccharins, haloalkanes, and Cs2CO3 as oxygen source.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1690178.
- Supporting Information
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