RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000131.xml
PDF herunterladen
Synfacts 2019; 15(07): 0749
DOI: 10.1055/s-0039-1689958
DOI: 10.1055/s-0039-1689958
Metals in Synthesis
Palladium-Catalyzed Generation of C1 Ammonium Enolates
Li L.-L,
Ding D,
Song J,
Han Z.-Y.
*
Gong L.-Z.
* University of Science and Technology of China, Hefei and Collaborative Innovation
Center of Chemical Science and Engineering, Tianjin, P. R. of China
Catalytic Generation of C1 Ammonium Enolates from Halides and CO for Asymmetric Cascade Reactions.
Angew. Chem. Int. Ed. 2019;
58: 7647-7651
Catalytic Generation of C1 Ammonium Enolates from Halides and CO for Asymmetric Cascade Reactions.
Angew. Chem. Int. Ed. 2019;
58: 7647-7651
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
17. Juni 2019 (online)
Significance
The authors disclose a palladium-catalyzed generation of C1 ammonium enolates from readily available halides, carbon monoxide, and catalytic chiral Lewis base. The intermediate participated in asymmetric reactions with ketimines.
MissingLinkText
Comment
The chiral dihydropyridone and β-lactam products were obtained in high yields, high diastereoselectivities, and excellent enantioselectivities. This methodology was employed in the asymmetric synthesis of an antiproliferative agent.
MissingLinkText
MissingLinkText